Principal Investigator: Dr Martijn Spruit
Program Development Centre
Summary of 2 approved research proposals
- An abnormal low fat-free mass index (FFMI) occurs frequently in patients with chronic organ failure, such as chronic obstructive pulmonary disease (COPD), and is a strong determinant of morbidity and mortality. Moreover, FFMI provides information on prognosis in addition to body mass index. Therefore, assessment of FFMI should be considered in the routine assessment of COPD. The current gender-specific cut off values for an abnormal low FFMI are based on the lowest 10th percentile of the general population (mean BMI: 26 kg/m2). Nevertheless, in daily clinical practice, many COPD patients who are overweight (25-30 kg/m2) or obese (>30 kg/m2) do not have an abnormal low FFMI. We aim to develop BMI-specific cut offs for abnormal low FFMI in men and women that can be applied in the clinical setting and used as a global standard, irrespective of the underlying disease. This project requires baseline data on participants with lung function and impedance measures who are over 45 years at recruitment.
- Distal weakness generally predominates in patients with polyneuropathy and may contribute to deficits in daily activities and social participation. Therefore, reliable assessment of hand grip strength is important to capture clinical changes in interventional studies in these disorders. Assessment of hand grip strength has also been shown to be a prognostic indicator of clinical and functional recovery in other diseases affecting hand function and is a determinant of morbidity and mortality in elderly individuals with acute or chronic diseases. The Jamar dynamometer has been widely used in various chronic illnesses and has demonstrated its strength as a potential prognostic indicator. Various stratified normative values have been published using different methodologies in small-sized groups, leading to conflicting results. This project aims to determine age-specific, gender-specific and BMI-specific normative values of hand grip strength, which can be applied in daily clinical practice throughout the world. This project requires the use of baseline data on hand grip strength, impedance measures and self-reported illness in the full cohort.