Principal Investigator: Professor Tim Key
Department: Cancer Epidemiology Unit
Institution: University of Oxford
Cancer Epidemiology Unit
Richard Doll Building
Oxford, OX3 7LF
Previous research has shown that hormonal factors are important
determinants of breast cancer risk, but understanding of these effects isfar from complete. We propose a research programme on hormonal,
reproductive and dietary factors and breast cancer risk; this will extend the work of two existing consortia co-ordinated in the Cancer
Epidemiology Unit Oxford, the Collaborative Group on Hormonal Factorsand Breast Cancer, and the Endogenous Hormones and Breast Cancer Collaborative Group.
In phase 1 we will describe the distributions of established and potential breast cancer risk factors in the UK Biobank, including reproductive factors, anthropometry, hormone use, alcohol intake and physical activity.
In phase 2 we will examine the associations of established and potential risk factors with the concentrations of serum biomarkers relevant to breast cancer, which are soon to be measured for all participants by UK Biobank, including sex hormones and growth factors.
In phase 3, when at least 2,000 incident breast cancer cases have
accrued, we will examine the associations of breast cancer risk with
reproductive and lifestyle factors, and serum hormones.
In phase 4, the data accrued will be combined with the data collected by the Collaborative Group on Hormonal Factors and Breast Cancer, and the Endogenous Hormones and Breast Cancer Collaborative Group and new analyses of the worldwide evidence will be produced.
Project Extension – to expand the scope to include SNPs associated with body mass index, in order to look at the relationships between these variants and Biobank’s various anthropometric variables, physical activity level, and eventually breast cancer risk.