Principal Investigator: Dr Soren Brage
Department: MRC Epidemiology Department, Addenbrookes Hospital
MRC Epidemiology Department
Institute of Metabolic Science
Addenbrookes Hospital, Cambridge
Physical activity (e.g. exercise or cycling to work) and sedentary
behaviours (e.g. TV viewing) are both implicated in the development of
heart disease and premature mortality. Intermediate heart disease
markers include blood pressure and the stiffness of blood vessels.
The interplay of lifestyle exposures and their pathways to disease are
not fully understood but are likely to involve both direct and indirect
influence on the cardiovascular system. The role of adiposity as a
potential mediator of these relationships remains uncertain, as does the
degree to which these relationships are consistent across sociodemographic
The aim of the current cross-sectional investigation is to examine the
separate and combined associations between physical activity and
sedentary behaviours with markers of vascular function in the UK adult
population. This will inform prevention strategies that tackle important
contributors to heart disease and early death in the UK.
This project involves a cross-sectional analysis of baseline variables. We
require access to data only (not samples) for the full cohort.
This research will look into the effect of electronic device use on selfreported
health conditions at baseline and on health outcomes over the
longer-term. Given the changing lifestyle conditions as a result of
broadband technology adoption and use we intend to analyze the effects of the use of computer games, internet use and mobile phone
use on the physical and mental health of the UK Biobank population.
Building on information across different levels of usage intensities we
will frame our project in three phases:
- In the first phase we conduct a cross-sectional analysis to identify associations between use of electronic devices, other lifestyle factors (such as physical activity, alcohol use, socio-demographics, psychological factors and others) and self-reported health conditions.
- In the second phase, we will identify changes in electronic device over time using data from the repeat assessment.
- In the third phase, we will assess the association of electronic device use on a whole range of health outcomes, including hypertension, dementia, etc.
This work seeks to expand our understanding of the impending lifestyle
changes through information technology use on health.