Principal Investigator: Dr Josep M Mercader
Department: Life Sciences Department
Barcelona Supercomputing Center, Life Sciences Department, C/Jordi
Girona 29, Barcelona, Catalunya 08031, Spain
1a: We have recently developed novel methodologies and approaches to reanalyze
existing GWAS data through combined genotype imputation of several
reference panels. We propose to use the UK Biobank as a replication dataset for
the current findings. Our studies are focused on type 2 diabetes and related
clinical variables such as glycemic traits. I would be also interested in obtaining
primary care data and adjudicated diabetes when available.
1b: The discovery of variants associated to metabolic diseases are key to
generate novel hypothesis for the diagnosis, treatment, prevention, and early
detection of the disease. In that sense, the UK Biobank will help replicate, and
enhance the power of our current studies. It therefore, clearly meets the UK
Biobank stated purpose.
1c: We have identified a subset of genetic variants associated with type 2
diabetes (T2D). In order to confirm these findings, and also to strengthen the
power, we will meta-analyze the results we obtained in our discovery sample
with the results obtained in the UK Biobank
1d: We intend to use the full cohort, and compare all the individuals suffering
the metabolic condition, i. e. type 2 diabetes, with the rest of individuals not
suffering this disease.