Principal Investigator: Mr Joseph Firth
Department: Brain, Behaviour and Mental Health, Jean McFarlane Building, University of Manchester, Oxford Road, Manchester
Institution: University of Manchester
Lead Collaborators: 1) Dr Brendon Stubbs
Collaborating Institutions and Addresses: 1) King’s College London, Health Services and Population Research, Denmark Hill, London, SE5 8AZ, United KingdomTags: 22125, bipolar, cognition, exercise, fitness, neurology, psychosis
1a: The aim of this research is to explore how different types of physical activity and exercise are associated with brain structure, connectivity, and functioning in people with serious mental disorders (including schizophrenia and related psychotic disorders, major depression and / or bipolar disorder). This will help to determine the optimal frequency, intensity and modalities of exercise interventions for improving functional outcomes in people with mental illness.
1b: Serious mental illness (SMI) is associated with various neurocognitive impairments, which are predictive of poor social and occupational functioning. Research in healthy samples has shown physical activity can improve various aspects of neuro-cognition. However, the optimal types of activity and exercise for improving cognition in SMI has yet to be established. This research will determine what frequencies, modalities and intensities of exercise are most associated with greater cognitive functioning among people with SMI, to inform future physical activity interventions for improving their neuro-cognition and quality of life.
1c: Physical exercise has been shown to improve neuro-cognition in the general population. In this project, we will use self-reported physical activity, accelerometry and cardiorespiratory fitness data from people with SMI, in order to examine how different types and intensities of exercise are correlated with brain structure and functioning.
1d: Full cohort