Principal Investigator: Professor Luda Diatchenko
Department: McGill University, Anesthesia, 740 Dr Penfield, Montreal H3A0G1. Canada.Tags: 20802, anxiety, comorbidities, GWAS, pain, sleep
1a: It is known that 50-70% of chronic pain patients complain about poor sleep quality. A circular relationship is suggested between poor sleep and more pain. Given the important overlap between sleep disturbances and chronic pain, it is crucial to identify genetic aethiology behind this interaction. Recently, we discovered genome-wide associations with sleep, pain and various related phenotypes, including anxiety. In this context we are seeking a replication study to analyse the interaction between sleep, pain, anxiety and genetic variants. We seek an opportunity to evaluate these associations in the UK biobank resources.
1b: The results generated from this project will help understand the dynamics of this interaction and will provide clues for the development of safe and effective treatments.
1c: Statistical models will be employed to analyze association between genotype and phenotypic measurements of sleep and pain. Linear regression models that incorporate age, gender and race will be used for association studies. Related comorbidities will be analyzed using a multivariate model.
1d: Full cohort, with the possibility of adding data from the future web-based questionnaire on pain.