Principal Investigator: Professor Nishi Chaturvedi
Department: Institute of Cardiovascular Science, Gower Street, London W1E 6BT, United Kingdom
Institution: University College London (UCL)
Lead Collaborators: 1) Professor Liam Smeeth
Collaborating Institutions and Addresses: 1) London School of Hygiene and Tropical Medicine, Epidemiology, Keppel Street, London WC1E 7HT, United KingdomTags: 21893, Age, diabetes, ethnicity, gender, gripstrength, mortality
1b: Previous research has identified a strong association between reduced muscular strength, major disease outcomes and mortality. Importantly, these have not been well studied in the elderly and ethnic minority subgroups, who may have some degree of sarcopenia, with variable effects on grip strength and thus on outcomes.
We will investigate the predictive value of grip strength for individuals with and without diabetes in these populations. UK By defining the role of grip strength in cardiovascular disease outcomes and mortality, we aim to improve the prevention and diagnosis of these diseases, in line with UKB’s core goals.
1c: This will be a prospective cohort study examining time to all-cause mortality, cardiovascular mortality, non-cardiovascular mortality, and a range of CVD end points in a competing risks framework, where death is considered to have precluded the risk of any other non-fatal endpoint occurring. The primary predictor will be grip strength.
1d: We intend to use the full dataset of approximately 500,000 people. The study population will be drawn from all UKB participants with a grip strength measurement at baseline.
The population will be stratified according to the presence of diabetes mellitus (both type 1 and type 2) at baseline. 501,721 have had their diabetes status recorded at baseline, of whom 22,887 have had diabetes recorded by a doctor (4.6%)