Principal Investigator: Professor John Gallacher
Institution: University of OxfordTags: 15697, cognition, Dementia, Lifestyle Ageing, neurodegeneration
1) University of Cambridge, Public Health and Primary Care, Forvie Site, Robinson Way, Cambridge, CB2 0SR, United Kingdom
2) University of Edinburgh, Centre for Clinical Brain Sciences, Chancellor’s Building (room FU303), 49 Little France Crescent, Edinburgh, EH16 4SB, United Kingdom
3) University College London, Dementia Research Centre, NHNN, 8-11 Queen Square, London, WC1N 3BG, United Kingdom
4) Cardiff University, Psychological Medicine, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ, United Kingdom
5) Imperial College London, Division of Brain Sciences, Department of Medicine, Hammersmith Hospital, DuCane Road, London, W12 0NN, United Kingdom
6) Swansea University, College of Medicine, Singleton Park, Swansea, SA2 8PP, United Kingdom
1a: The MRC Dementias Platform UK (DPUK) is a multi-cohort collaboration. This proposal is to use UKB data alongside that of other cohorts to investigate the determinants of dementia. To do this we will need to compare cognitive and lifestyle data in those with and without dementia. We will need to take account of co-morbidities, family history, genetics imaging and biomarkers.
1b: Dementia is a major public health problem and one of the chronic diseases that UKB was established to investigate
1c: We will compare risk factors for dementia prevalence and incidence within cohorts and between cohorts. This is a statistical analysis of existing data.
UKB will be used to generate hypotheses which will be tested in confirmatory analyses using other DPUK cohorts.
1d: full cohort