Last updated Feb 21, 2019
Recently approved research (2017-2019) with the UK Biobank resource is listed below by month of data release. You can search by keyword or year. You can also enter locations and researcher names into the search box to find the results you are looking for. The chart below details research interest areas from 2012-2019, please click on the chart to enlarge it.
Approved Research
The environmental and genetic basis of Interstitial Lung Disease
Tags: 44046, featured, genetic association, interstitial-lung-disease, patient stratification, pre-disposition, progression, pulmonary fibrosis
August 2019
Cognitive, auditory and other health outcomes after subarachnoid haemorrhage, and genetic determinants
Tags: 49305, Brain, cognition, genetics, genotyping, hearing, outcomes, subarachnoid-haemorrhage
August 2019
Investigation of the role of Copy Number Variants in the missing heritability of complex phenotypes
Tags: 45408, complex phenotypes, copy-number variants, GWAS, heritability, Machine Learning
July 2019
Development and application of bioinformatics methods to better understand the genetic architecture and components of diseases and complex traits disorders across human populations
Association between citrus consumption and skin cancer: an analysis of risk and nutrient-gene interaction
Development and validation of polygenic risk scores for complex traits and diseases
Genetic risk, environmental factors and chronic diseases and ageing outcomes
Towards optimal human performance: Discovering molecular mechanisms of human phenotypes
Association of Brain Structure and Dementia
Statistical modeling of retinal features and their association with disease relevant phenotypes
Does longer compulsory schooling affect mental health? Evidence from a British reform
Cerebral correlates of the APOE and other genetic risk factors for Alzheimer’s disease in healthy middle-aged individuals
Replication of association of metabolically healthy obesity (MHO) with risk of cardiovascular and total mortality in the UK Biobank
Statistical Analysis of Human Brain Connectomes
Combining genetic analysis of disease related phenotypes with in vitro disease models for development of high efficacy and low toxicity therapeutics
Improved Polygenic Risk Score Calculation and Sub-classification of Disease by the Incorporation of Functional Data
Evaluate the causal effects of dietmodifiable biomarkers on clinical outcomes using Mendelian randomization
To decode the mystery of longevity
Machine learning based quantitative analysis of human sleep
Tailoring exercise to maintain cognitive health: Is benefit moderated by genetics and gender?
Artificial intelligence methods applied to cardiovascular MRI segmentation
Unravelling the genetic architecture of diabetic retinopathy
Methods for multivariate analysis of genetic and environmental factors
Molecular underpinnings of resting-state fMRI
Estimates of allele age and impact in large data sets
A Genome-Wide Association Study (GWAS) of biological age measures in UK Biobank, with a focus on genetic variations of collagens, elastin and pro-inflammatory cytokines
Association between ketohexokinase mutations and adverse cardiovascular risk factors and outcomes
Infer genome-wide cell-type specific regulatory element activity for phenotypes of the UK Biobank
A Study Investigating Leukocyte Counts in Women with Self-reported Polycystic Ovarian Syndrome: Results from the UK BioBank Prospective Study
Hormone processing in health and disease
Do persons with epilepsy (PWE) have known pathogenic mutations in ion channel or other known sudden cardiac arrest-related genes at a greater frequency than non-epileptics?
Patient stratification using machine learning on literature and clinical datasets
Dissecting predisposition and risk prediction for cardiometabolic disease, cancer and their co-occurrence: a trans-ethnic study
Evaluating Biomarkers in Predicting Ovarian Cancer Risk
Computational analyses of genotypic and phenotypic data with treatment response from patients with multimorbidity and the role of inflammation as a driver of multimorbidity
Automated segmentation of visceral organs and tissues in whole body MRI
Developing statistical methods and computational algorithms for identifying biomarkers at Biobank-data scale for cardio-metabolic traits
Tags: 48152, algorithms, big data, cardiometabolic, cognitive function, Distributed computation, Integrative Analysis
July 2019
Exploring the genetic basis of healthy development and ageing: gene discovery and methods development
Coffee and the risk of chronic diseases, including liver cancer, liver cirrhosis, type 2 diabetes mellitus and chronic kidney disease
Determinants of somatic mutation variability in the UK Biobank population
Investigating the interplay between gender and shiftwork in the development of metabolic syndrome
Integration of regulatory elements and multi-trait genomic and phenomic data to improve the accuracy of risk prediction of human complex diseases/traits
Pancreatic Disease Haplotype Association Studies
Genome-wide association study of takotsubo syndrome
Analysing the effects of privacy protection methods on data utility and data research generalisability in observational studies: A case study in asthma
Electrophysiological remodelling in patients at elevated risk of ventricular arrhythmia and sudden cardiac death
From data to targeted interventions: Paving the way to relieve the burden of mental-non-mental multimorbidity by a deep learning-informed translational network approach
Analysis of the UK Biobank population prevalence, penetrance and effects of risk variants associated with Parkinsonism and related movement disorders
Socioeconomic status and cognitive function: the influence of cardiovascular and brain health
Pathfinding Algorithms for Extracting Health-Related Insights from Raw Accelerometry
Gestational Diabetes and subsequent Type 2 Diabetes
The relationship between pain, social exclusion, anxiety, depression and related psychological problems
Mendelian randomization analysis on blood cell indices and blood pressure-related traits
Whole Genome Imputation of UK Biobank participants in partnership with Genomics England
Machine learning to assess biological age and predict disease from multimodality medical imaging
Tags: 51853, aging, Convolutional-Neural-Network, deep learning, featured, Machine Learning, prognosis, risk prediction
July 2019
Generative Model on brain decoding
Determining the Genetic Basis of Rotator Cuff Tearing
Genetic predictors of predisposition for and consequences of substance use behaviors and other neuropsychiatric traits and medical conditions.
Applying (deep) machine learning methods for understanding the complex relationship between genes and phenotype
The joint effects of genetic, lifestyle and environmental risk factors on common diseases and multimorbidity
Long term dairy consumption and colorectal cancer risk in adulthood
What is the vitamin D status of people with MS in the UK, how does this interact with risk factors associated with MS development, and what are the downstream consequences?
Brain allometry and asymmetries as intermediate phenotypes between genetic and environmental factors, and cognitive function and mental health
Applying Deep Learning to Understand Disease-Genotype Relationships
Adherence to dietary patterns, genetic predisposition and incidence of coronary artery disease
The health of teachers (and former teachers) in the UK.
Learning Intergenic Interactions Shaping Human Genotype-Phenotype Relations
How Does Physical Activity Differ Between the Healthy Population, Patients with Knee Pain, and Patients after Knee Replacement?
The hazards of smoking and benefits of cessation on cause-specific mortality in the UK by age, sex and social status.
Deciphering AMD by deep phenotyping and machine learning- PINNACLE
Disentangling the role of insulin resistance in diabetes, cardiometabolic disease and cancer to find new therapeutic targets
Validation of polygenic risk scores, based upon pooled discovery studies, for predisposition to major prevalent diseases affecting both quality-of-life and lifespan and testing for causation.
Association of immune GWAS loci with brain structure, function, and mental health
Genetic causes of polycystic kidney disease
The Impact of the Built Environment on Health and Wellbeing: Promoting Active Travel
Hidden scarcity: Commuting induced time poverty and healthy lifestyles of low SES subjects
Identification of genomic and microenvironmental factors in high-risk populations for pancreatic cancer
Investigating the relationship between air quality and health outcomes.
Fine-scale reconstruction of population structure and Admixture Mapping in British and South Asian populations
Metabolic Pathways in Heart Failure
The role of genetic, environmental factors and their interactions in the development of diabetes and its related health conditions under different ethnicity: comparison of East Asians and Europeans
Using human population sequencing data to explore protein structure and function
Relationships between blood, urinary and other biomarkers and risk of human non-communicable diseases, all-cause mortality, and cause-specific mortality
Analysis of human daily activity, cognitive function, and well-being
Statistical methods development for integrating genomic and multi-scale data
A study of genes implicated in Leber congenital amaurosis (LCA) and the role of preconception genetic screening
Tags: 44316, allele frequency, featured, genetic disease, leber congenital amaurosis, preconception genetic testing
July 2019
Epigenomics-mediated blood pressure and QT GWAS
The metabolic consequences of adverse early life conditions and subsequent risk for adult cardiovascular disease and type 2 diabetes
Tags: 47673, cardiometabolic, cardiovascular disease, development, diabetes, Machine Learning, mediation
June 2019
Running Principle Component Analysis and feature selection methods on Biobank scale genotypes
Predict the risk of type 2 diabetes based on early stage and late stage risk factors: genomics, bio-marker, lifestyle, MRI image and environmental data using a deep learning model
Evaluation of Causal Relationships between Body Mass Index and a Wide Range of Traits and Diseases
Gene-environment interaction study on obesity, body mass index, and waist circumference
A Secondary Data Analysis Case-control Study to Evaluate Dietary Intake before a Colorectal Cancer Diagnosis in the British Population
Identification and validation of causal variants effect on cardiovascular disease through immune-mediated inflammation
Genetic Determinants of Cardiorespiratory Fitness and Related Measures
Serum cardiometabolic and liver function markers in relation to colorectal cancer risk and survival
Effect of diet and diet-gene interactions on cognitive function and risk of dementia and Alzheimer’s disease.
Exploring and Accommodating Heterogeneity in Large-Scale Genetic Analyses
Understanding the genetic complexity of neuropsychiatric features in copy-number variant disorders
Precision Retinal Biomarkers for Cognitive Impairment
Detecting gene-gene interaction effect on blood cell traits by neural networks
Brain Aging Polygenic Risk Score Prediction of Neurological Phenotypes
Exploring mechanistic dietary patterns for obesity, type 2 diabetes and coronary heart disease
The Impact of Education on Pain: Evidence from Compulsory Schooling Laws
High-throughput detection of genealogical distortions due to selection
Characterizing the genetic determinants of mineral metabolism: A UK Biobank study
Identifying genetic correlations and significant regulatory mechanisms between mental disorders and autoimmune diseases.
Testing the role of positive selection in recent rises of disease incidences
Can 7-day wrist-worn accelerometry predicts hand grip strength in healthy older adults and people with multimorbidities?
Genetics of cancer risk and therapy response
Development of a predictive model for waist circumference for comparison of measurement methods between research studies
Cross-Modality Cardiac Scar Imaging
Importance of healthy lifestyle on chronic neurological conditions
Genetic Association Analyses of Complex Traits and Methods Development
Dissecting the genetic architecture of neurodegenerative diseases
Health economics of obesity
A Novel Reward System Polygenic Risk Score for the Prediction of Obesity and Substance Use Disorders
Refining an algorithm to identify individuals at the prediagnostic phase of Parkinson’s disease
Tags: 14872, ageing, Cognitive-decline, featured, modelling, neurodegeneration, prevention, risk factors
June 2019
Bayesian Models for Gene and Behavioral Interaction on Cancer and Cardiovascular Morbidity and Mortality
Tags: 44084, Bayesian, cancer, cardiovascular disease, effect modification, gene-environment interaction, physical activity
May 2019
Machine-Learning to Bridge Heterogeneity in Clinical Data Resources and Optimize Model Generation
Characterizing brain networks and their inter-individual variability by high-throughput imaging and computational modelling
Integrative analysis of UK Biobank and other genetic and genomic datasets for complex disease detection and prevention
D+ART: The diet and arthritis data project
GWAS studies for kidney-related traits using UKBB data
Identification of risk factors for venous thromboembolism
Development of cross-phenotype meta-analysis methods that can account for effect size heterogeneity between diseases and sample overlap
The impact of variation in the mitochondrial genome and transcriptome on human disease and phenotypes
Development and validation of polygenic risk score models for human traits and disease
Identification of subgroups in heterogeneous and multifactorial disorders
The association between occupational physical activity and the risk of gastroesophageal reflux disease (GORD), Barrett’s oesophagus and oesophageal adenocarcinoma – a cohort study in Biobank
Reprocessing and joint calling of UKBB exomes with gnomAD, genotype-phenotype analysis and open release via dedicated portals
Statistical methods for large-scale genomic analysis
Development of a composite genetic, comorbid, and lifestyle factor related risk prediction model for gout, and cardiovascular diseases in people with gout
Exploring Diet/Lifestyle/Health factors as causes and modifiers of genetic determinants of healthspan, ageing and longevity
Marker selection method to increase the accuracy of genomic prediction for human traits
How large is large enough? Is small datasets still valuable under the shadow of huge biobank data?
Towards a comprehensive predictive model of the contribution of individual and combination of risk factors to brain ageing, neurodegeneration, and cognitive decline
The UK Biobank and the porphyrias: investigating the consequences of mutations in genes related to heme biosynthesis
Tags: 47222, acute-intermittent-porphyria, pathogenic-mutations, penetrance, porphyria, Risk, subclinical-disease
May 2019
Prioritizing drug targets through genetic analyses
Genetic underpinnings of brain structural trajectories in health and psychiatric disease
Predicting cancer diagnoses from germ line copy number variation.
The role of metabolic and cardiovascular disease and treatments in dementia and cognitive decline
Gene x environment interactions between genetic variants and ethanol intake on triglyceride levels, liver and pancreatic diseases
Novel whole-genome analysis methods for Alzheimer’s risk prediction
Impact of red and processed meat and fibre intake on risk of chronic inflammatory diseases: a prospective UK Biobank cohort study on prognostic factors and personalised medicine in the UK Biobank
Understanding the genetic susceptibility to appendicitis
Understanding the genetic architecture of inherited cardiovascular conditions (ICCs) and cardio-renal disease
Characterizing the contribution of short tandem repeats to human phenotypes
Genetic and environmental interactions in genetics of human traits: Insights from regulatory variation
Predicting likelihood of developing gastrointestinal cancers
Fracture risk in the Million Women Study cohort: application for baseline information from UK Biobank for women participating in both studies
Understanding genetic and phenotypic contributors to complex disease risk
Developing a reference normative sample of the volumetric and myelin density of the spinal cord and brain imaging data in the UK Biobank
Replication of genetic risk factors in sporadic Creutzfeldt-Jakob disease
Predictive value of the structural connectome using machine learning
Resting state functional Magnetic Resonance Imaging (fMRI)-based markers of chronic pain
The genetic basis of postoperative atrial fibrillation after cardiac surgery
Tags: 47429, Atrial Fibrillation, Cardiac, cardiac surgery, genetics/genotyping, Pharmacogenomics, risk prediction
April 2019
