Last updated Feb 21, 2019
Recently approved research (2017-2019) with the UK Biobank resource is listed below by month of data release. You can search by keyword or year. You can also enter locations and researcher names into the search box to find the results you are looking for. The chart below details research interest areas from 2012-2019, please click on the chart to enlarge it.
Approved Research
Development of a polygenic risk score for mitochondrial (dys)functioning to predict the development of common late-onset diseases
Tags: 60406, common-(late-onset)-disorders, diabetes, exome-data, mitochondrial-(dys)functioning, mtdna, polygenic risk score
June 2020
Multi-omics analyses of psychiatric and neurological disorders
Development and validation of an automated QC process for brain MRI and associated endpoints (e.g. volumetric segmentation) for the application in CNS clinical trials
The association of vascular and systemic inflammation with cerebrovascular diseases and its related outcomes
Causal associations of novel and established cardiovascular risk factors with type 2 diabetes, kidney disease, lung disease and cardiovascular disease in UK Biobank
Predicting adverse outcomes from genomic data using machine learning models and localization
The development of an Alzheimer’s disease (AD) clinical trial simulator, parameter estimation from international patient cohorts and standardising epidemiological measurement platforms for cohort study
Multi-omics analyses of psychiatric and neurological disorders
Tags: 58259, Alzheimer disease, Dementia, depression, expression, genotyping, personality-traits
June 2020
Using UK Biobank participants as control subjects in genetic studies of Mendelian and complex diseases
Survival analysis with an explainable tree-based machine learning model
Improve polygenic risk prediction for non-European populations
Genetic variation in sodium-glucose cotransporter 2 (SGLT2) and glucagon-like peptide-1 receptor (GLP1R) and cardiovascular outcomes
Development of the phenome-wide biological age prediction model with application of artificial intelligence
Constructing a genetic effect network to predict polygenic disease risk
Single nucleotide polymorphisms associated with PD-1 inhibitor treatment response in stage III melanoma patients
Linking psychological well-being measures to brain and health biomarkers to understand aging and risk of dementia
Using UK Biobank data to support the Novartis drug discovery and development pipeline
Tags: 59456, Drug development, Drug target, epidemiology, patient stratification, PheWAS, target-discovery
May 2020
Phenotypic Consequences of Strong Positive Selective Sweeps
Lifestyle behavior-biomarker interactions on cancer
Polygenic prediction of imaging for functional characterization of psychiatric GWAS
New investigations of associations between mosaic loss of chromosome Y (LOY) and other somatic mutations in blood cells with increased risk for human disease outcomes
Identifying epilepsy in UK Biobank: a validation study of primary care, hospital admissions, prescribing, and mortality data
The role of polygenic risk scores in ovarian cancer survival across the risk spectrum
Exploring the causal intersection of cancer and cardiovascular disease
Analysis of shared genetic determinants across major complex human disorders
Genetic variation in incidence and outcome of cancer and infectious disease
Social and Environmental Adversity in Relation to All-Cause Mortality
Establishment and characterization of polygenic risk scores for geriatric diseases such as cognitive impairment in both European and non-European populations
Integrating Clinical Model, Polygenic Risk Score, and Machine Learning Models in the Prediction of Cardio-Metabolic Disease Using an Ensemble Approach
Construct a composite wellbeing measurement and resilience scale in UK-biobank, for use in GWAS on wellbeing and resilience
Genetic and non-genetic determinants of cardiovascular disease, cerebrovascular disease, and aging
A biopsychosocial model of the effect of social support on mental health in middle- to older-aged adults
Tags: 54646, mental health, neuroimaging, neuroticism, social support, socio-economic-status, Structural equation modelling
May 2020
Differentiating causal risk factors and proximity markers for dementia
Tags: 59138, biomarker-discovery, Dementia, early diagnosis, EWAS, prevention, risk factors
May 2020
Investigating the genetic architecture associated with skeletal body proportions
Lean tissues as determinants of body shape and cardiometabolic health
Venous ulceration: assessment of clinical and sociodemographic risk factors using UK Biobank and machine learning
Tags: 61217, chronic disease, epidemiology, Machine Learning, risk factors, risk prediction, venous ulceration
May 2020
Evolutionary analysis of ageing and age-related disorders in the extant human population
Multi-omics analysis of vascular and cardiac disease
Application of machine learning for depression classification and outcome prediction
Uncover protective rare variants in aging pathways against age-related diseases
Defining the role of CRYBG1 germline alterations on tumor incidence and progression
Development of a novel multi-dimensional polygenic risk score method that better predicts complex disease
Association of Fundus Imaging Findings with Risk of Dementia and Premature Death
Machine learning prediction of common disease risks and disease network construction using multi-source data
Unlocking the Clinical Utility of Brain Connectomics via Latent Structure Modeling
Genome-Wide Association Studies for COVID-19 and Its Outcomes
iCor: stratification of patients with cardiovascular risk using AI-powered automatic retinal imaging as a surrogate for Small Vessel Disease
Assessing metformin use in T2D patients to suppress autoimmune diseases
Influence of genetic architecture on polygenic prediction
Tags: 56579, Genetic architecture, genetic interactions, Heterogeneity, polygenic prediction, polygenic risk score
May 2020
Predicting Outlier Phenotypes from SNPs using Molecular Biology
Tags: 45329, computation, genetics/genotyping, molecular biology, outlier, phenotype, prediction
April 2020
Estimating the overall impact of genetic variation on morbidity and mortality and assessing differential risk conditional on environmental and genetic factors
Lipid levels and risk of spontaneous intracerebral hemorrhage: a mendelian randomization study
Retinal fundus photographs to predict diabetes: A potential solution for community-based diabetes screening in low- and middle-income countries
Advanced Risk Prediction and Heritability Estimation Methods
Antibiotic use and dementia risk or cognitive change
Uncover the genetic and phenotypic background for the disease network influencing women’s life course health
Supporting the discovery and evaluation of drug targets and biomarkers for therapeutic areas that are in scope of Boehringer Ingelheim’s R&D through analyses of UK Biobank data
The Long-Term Effects of Excess Sugar Consumption in Early Childhood
Assessing the associations between the use of common non-cancer medications and the risk of cancer at selected sites
Determinants and environmental correlates of asthma attacks in UK Biobank
Identifying novel genes and biomarkers using genetic instruments and assessing utility of risk prediction models for pancreatic, prostate, and endometrial cancer
Evaluation of a causal association between testosterone levels, dementia, and adverse mental health outcomes
Genomic Determinants Underlying Cardiovascular Disease Susceptibility
Understanding the social outcomes of survivors of critical illness: a cross sectional population study of UK Biobank participants
Statistical machine learning of wearable sensor data to predict disease outcomes
Sleep, circadian rhythm, and human body composition – a Mendelian randomization study
Targeted PheWAS of IFNL4 Genotype and Infectious Phenotypes and Mortality
Monitoring tumour burden in circulating free DNA by low coverage whole genome sequencing
Impact of physical fitness and physical activity on cardiovascular health in prevalent and incident breast, prostate, lung, & colorectal cancer participants of the UK Biobank study
Polygenic Evaluation of Gene-Environment interactions In Complex Traits
Developing computational assays for personalised predictions in psychiatric disorders
The Individual and Joint Effects of Cardiorespiratory Fitness and Body Mass Index and Breast Cancer Incidence and Mortality
Deep Learning Human Genetics to Enhance Discovery of Genetic Disease Associations
Tags: 55964, artificial intelligence, deep learning, feature reduction, genetics/genotyping, Machine Learning
April 2020
The effects of age, metabolism, genotype and systemic health on cognitive health
Tags: 60124, comorbidities, Dementia, Mendelian randomisation, Metabolism, neuroimaging, prevention
April 2020
Assessment of the heart-brain-liver-axis in the UK Biobank Imaging study
Prospective study of epidemiologic and genetic risk factors for pancreatic cancer
Lifestyle and genetic factors and bladder cancer risk
Learning Multimodal Representations for the Prediction of Human Disease
Investigating the diabetes-related metabolic and vascular risk factors that contribute to functional & neurodegeneration brain ageing
The Beethoven Genome Project
The Impact of Genetic QT score on Mortality in Patients with Obstructive Sleep Apnea
Pathway and network analysis of the genotype to phenotype relationship
Tags: 51573, biological-pathways, Epistasis, functional-modules, heritability, interactions, network analysis
April 2020
Genome-wide association studies of kidney diseases and phenome-wide association studies of putative targets
Assessing the prevalence, penetrance and pathogenicity of rare genomic variants
Gender-specific multi-modal phenotyping of hypertensive disease
Genetic regulation of traits and disorders affecting women’s reproductive health
Common and rare TRAF3 variants influence B cell survival and immunoglobulin levels
Risk factors, structural brain abnormalities and cognitive function in individuals with type 2 diabetes
Establishing the biological importance of germline variants in SMARCA4
Association between cerebrovascular disease and Parkinson disease
Tags: 58919, biomarkers, brain MRI, cerebrovascular, Parkinson disease, Parkinsonism, white matter hyperintensity
April 2020
Modelling organ function in health and disease
Age-related hearing loss, brain health and genetic risk for Alzheimer’s
The effect of blood pressure-lowering drugs and drug-drug interactions on the risk of type 2 diabetes
A Genome-Wide and Phenome-Wide Association Study of Daytime Napping
Tags: 53562, daytime napping, featured, GWAS, Mendelian randomization, PheWAS, public health
April 2020
Cancer Incidence and Premature Mortality Associated Early Phenotypic Risk Markers related to Lifestyle, Diabetes Mellitus, Obesity, other Chronic Diseases: An UK Biobank Prospective Cohort Study
Gene-environment interactions in cardiovascular diseases: an integrated genomics and behavioral approach using multi-ancestry population
The effect of proton pump inhibitor use on the risk of nonalcoholic fatty Liver disease, alcohol related liver disease and acetaminophen induced liver injury
Association between non-invasive markers of liver fibrosis and chronic kidney disease in people with type 2 diabetes and the role of PNPLA3, TM6SF2 gene variants: cross-sectional analysis
Integrating genetic, biomarker, and health record data into the discovery and development of effective therapeutics
Aging Study by Genotype and DNA Methylation in Neural Networks
Microbiology, disease and genetics
Understanding the impact of rare DNA variants in molecular phenotypes & ophthalmic disease risk
Leveraging genetic and phenotypic data for genetic epidemiology and target prioritization
Lipoprotein(a) Distribution and Relation to Long-Term Cardiovascular Outcomes According to Sex, Ethnicity, LDL-C Levels, Prevalent Cardiovascular Disease and Diabetes Status, and Cholesterol-Lowering
Understanding Alzheimer’s Disease in the Context of the Aging
Precise Polygenic Risk Score
Identifying polymorphisms in GPR101 associated with inflammatory diseases
Detecting heterogeneity in GWAS traits from expected correlations between polygenic risk score predictors
Genetic variability in people with obstructive lung disease: variation in outcome, response to treatment and disease progression
Study of effects of common and rare genetic variants on health-related phenotypes
Building an Online Resource for Global Investigation and Validation of Trans-ethnic PheWAS Results
Surface based neuroimaging analysis to advance understanding of neurologic conditions
Patterns, outcomes and predictors of non-communicable diseases and multimorbidity
An exploration of how the neighbourhood environment, personal characteristics and genetic variations contribute to geographical variation in the prevalence of diabetes and obesity
Characterising multimorbidity and frailty associated with cardiometabolic disease
How does results from experimental model systems translate to human health?
Quantifying the relationship between drug targets and diseases using human genetics evidence
Tags: 59384, allelic-series, Drug development, drug-targets, open source, target-discovery, target-identification
March 2020
Application of machine learning methodologies on the UK biobank dataset to quantify the effect of lifestyle habits on health
Regulators of metabolic co-morbidities
Mapping the genetic basis of reproductive success and ongoing natural selection
Ethnicity and Mental Health: are the complex relationships best explained as a syndemic?
Adherence to cancer prevention recommendations and risk of in situ breast cancer
Tags: 55149, in-situ-breast-cancer, lifestyle, pre-diagnostic, prevention, recommendations, score
March 2020
Uncovering genetic and biological causes of cardio-metabolic disease and traits by integrated genetic, functional genomic, clinical, and imaging data
Tags: 56925, cardio-metabolic disease, Machine Learning, Mendelian randomization, phenome-wide-association-studies
March 2020
Brain changes associated with pregnancy
Mortality prediction based on routine blood indexes and biochemical parameters
Genetics of early-onset colorectal cancer
Tags: 53832, cancer, genetics/genotyping, mutation signatures, risk alleles, tp53 pro72 arg, young adult colorectal cancer
March 2020
Cardiac Analysis for Vascular Estimation (CAVE)
Identification of Genomic Risk Factors and Prediction of Cardiovascular Disease Risk through Deep Learning
Generating genetic prediction scores of circulating biomarker levels that can be leveraged as instrument variables in Mendelian Randomization analysis of complex traits
Dietary patterns and genetic predisposition to obesity, type 2 diabetes, and cardiovascular disease
Stratification of health outcomes in mood disorders
Comparative analyses of clinical phenotypes and genetic predisposition for cancer and emotional vulnerability across different ethnic populations
Use of transcriptomic and genomic data to predict risk of Abdominal Aortic Aneurysm
Impact of HRT use and APOE genotype on cognitive performance in menopause – implications for dementia risk reduction treatments
The identifications of environmental factors and daily habits that are associated with age-related changes in cognitive functions and neural mechanisms
Functional study of primate-specific genes based on genotype-phenotype data of UK Biobank
Tags: 54701, Human evolution, Population genomics, Primate-specific genes (PSGs), public health
March 2020
Genetic and non-genetic risks associated with non-alcoholic liver steatosis
Validation of automated analysis method on cardiac MRI image data
Brain substrates linking gastrointestinal symptoms and psychiatric disorders
The role of endolysosomal cation channels, particularly TPC2, in cancer prognosis, and diagnosis: novel therapeutic targets for cancer
Developing machine learning models of brain MRI for biomarker discovery of complex diseases
Establishing causal relations for circulating factors to cardiometabolic and neurodegenerative diseases
Understanding the relationship between genomics, eye imaging, and neurodegeneration
The causes and consequences of pleiotropy across the human phenome
Phenome-wide association and mendelian randomization studies of a weighted genetic risk score (wGRS) of CYP2A6, the gene for a nicotine and nitrosamine metabolizing enzyme
Understanding brain development with imaging genomics
Leveraging the power of Big Data to build more accurate models of neuro-anatomical and genetic variation: applications in neurodevelopmental research
Alcohol consumption and brain health
The role of two-pore channel 2 in monocyte differentiation as a novel therapeutic target for cancer
Deep learning research on idiopathic urology phenomena
Understanding the relationship between depression and trajectories of physical multimorbidity accrual: longitudinal analysis of UK Biobank data
Understanding Environmental and Intergenerational Effects on Genetic Measures and Longer Term Social, Economic, and Health Outcomes
Understanding mechanisms of increased ovarian cancer risk due to young age at menarche and a high number of lifetime ovulatory cycles
A Genome-Wide Association Study of Tinnitus to Identify Genes of Interest and Potential Therapeutic Targets
Deep Phenotyping of Major Depressive Disorder in Adults
Genomics-driven molecular refinement of the polygenic risk score of coronary heart disease
Birth weight and cardiometabolic diseases in adulthood
Tags: 57733, birth-weight, cardiometabolic, cardiovascular disease, Mendelian randomisation
March 2020
Clinical and genetic characterization of hypermobile Ehlers-Danlos Syndrome and Irritable bowel syndrome and in the UK Biobank cohort
Establishing a cardiovascular disease phenome and determination of gene-environment interaction in cardiovascular disease
Central and peripheral sympathetic nervous system activity in older adults: feasibility study on DPUK cohorts to obtain preliminary data (Pilot project funded by Early Career Researcher DPUK grant)
Developing chronic disease models to inform health policy and guide treatment decisions
Aetiology and prediction of cardiometabolic diseases, their comorbidities and complications
Tags: 55469, cardiovascular, causal inference, genetics/genotyping, metabolic, prediction
March 2020
Multi-trait trans-ethnic genetic analyses
Application of a deep learning system for detecting prediabetes based on eye image and life style
Prognostic value of movement quality parameters derived from wrist sensor data in a large population
Genetic predictors of neutrophil-to-lymphocyte ratio and its association with chronic disease incidence and mortality
Evaluating genetic risk of comorbidities in subjects with psychiatric disease
Investigating age at onset in bipolar disorder
An Epidemiological Study of Genetic and Clinical Factors Affecting the Progression of Age-related Macular Degeneration (AMD)
Validation of protective mutations for diseases related to transthyretin
Peripheral immunity and its role in differentiating between resilience and depression in adults with a history of childhood maltreatment
Machine Learning Analysis of Brain Images, Behaviors and Genotypes to Understand Aging and Mental Disorders
Polygenic Risk Scores And Mediating Risk Factors
Investigating the association between periodontal disease and systemic diseases
Delineating Germline Genes that Predispose to Cancer
Understand Alzheimer’s disease characterized by brain imaging phenotype
Stroke risk prediction using routine electronic health records enhanced by genetic data and machine learning
Genetic basis of body weight regulation in the population: comparison with extreme phenotypes of severe obesity and persistent thinness
Age Prediction from NeuroImaging and Genetic Profiles
Interaction of Diet Quality Scores and Genetic Variants in Relation to Cardiometabolic Traits
A Data Mining-based Workbench: Advancing Precision Medicine by the Use of Machine Learning and Expert Knowledge
Novel cerebral small vessel disease markers and their contribution to cognitive impairment and dementia
Exploring the genetic determinants of serum phosphate through large-scale GWAS Biobank approach: towards the elucidation of the genetic architecture of human serum phosphate
A genome wide association study in patients with Intracranial Atherosclerosis
Impact of treatment on cardiovascular outcomes amongst breast cancer participants in the UK Biobank
Prevention of myocardial infarction and primary atherogenic cardiovascular disease from a sex-specific life course perspective
Identifying gene-by-environment interplay in, and the genetic architecture of, health and human capital outcomes
Gene-Environment Interaction Analysis and Causal Inference on ADRD and Cognitive Decline
Polygenic effects of Alzheimer’s Disease associated genetic risk factors in the early life
Identification of genetic risk variants of non-alcoholic fatty liver disease
MR-based assessment of neurological/psychiatric disorders
Tags: 51347, artifact reduction, artificial neural networks, biomarker, Machine Learning, neuroimaging, segmentation
March 2020
Combining Genetic and Environmental Information to Predict Disease Risk
The associations between metals status and the risk of health-related outcomes and all-cause mortality: a Mendelian randomization-phenome-wide association study
Structural and functional changes in the brain tissue of “chemo(radiation)-brain” cancer survivors
Tags: 50796, cancer, chemoradiation, cognition, featured, Imaging, personalised medicine, prediction
Polygenic Risk Scores And Mediating Risk Factors
Obesity and cancer risk and overall and cancer specific mortality: the role of metabolic health and comorbidities
Which causes of death are predictable? A machine learning analysis
Genome Wide Gene Association Analysis of UK Biobank Data to Identify Novel Disease Associations
Analysis of Population Admixture and Its Implications for Studies of Dysmenorrhoea
Fast multivariate genotype by environment interactions identification algorithm with a linear mixed model/ logistic model framework
Impact of genetic and environmental factors on the health-related outcomes in chronic kidney disease patients
Understanding clonal haematopoiesis and the preclinical evolution of haematological cancers
Understanding the genetics of complex diseases/traits to identify potential drug targets and patient stratification markers
Searching the causal and risk factor for chronic immune mediated inflammatory disease
Tags: 47116, causal factor, chronic immune mediated inflammatory disease, Mendelian randomisation, risk factor, sle, spondyloarthritis
February 2020
Searching for genetic links between fertility disorders and other health outcomes
What does the alcohol harm paradox look like when evidenced from Biobank data?
GWA studies across African and European ethnicities to determine correlation in associated SNPs
Integrative Genomic and Imaging Analyses of Inherited Heart Diseases
Evaluating and comparing sequence variant associations between the deCODE and UK Biobank datasets across a range of human traits
Elucidating the genetic architecture and shared origins of chronic inflammatory diseases
Study circadian clock disruption in Alzheimer’s disease (AD) and other dementias of aging
Genetic variants that influence incidence, biological factors and clinical outcomes of sepsis and septic shock
Estimation of the arterial stiffness cut-off value at which there is an impact on brain structure and function
Decomposition of phenotype-dependent pleiotropic effects
After the plague: genetic history of medieval Cambridge population in relation to present-day population of Britain
Identifying diseases addressable by kinase therapies from real world healthcare data
A Multi-omics Data Integration Approach for Precision Medicine and Improved Clinical Trial Success
Unravelling the determinants of successful ageing by examining longevity
A precision health study based on UK Biobank data
Understanding associations between sleep and circadian disruption and mental health
Analysis of Gait Parameters assessed through Accelerometry in Rheumatic and Musculoskeletal Diseases (RMDs)
Frailty in older adults: epidemiological and genetic study
Understanding disease subtypes from genotype information
Genotype-Phenotype analysis of genetic kidney and liver diseases
Using UK Biobank data to investigate the biomolecular and genetic bases to myalgic encephalomyelitis (ME/CFS)
Identifying trait-causal mutations in UK biobank data using abundance-modified Mendelian Randomisation (AMMER)
Integrating the impact of exome variations
Development of robust therapeutic hypotheses through the integration of biomarker, genetic, imaging and deep clinical phenotypes
Identification of shared biomarkers for age-related multimorbidity
Biomarkers, lifestyle and body composition in relation to healthy aging
Pharmacogenomics to improve drug efficacy and safety
Constructing risk scores of longevity, dementia, and related disorders
Tags: 54520, Alzheimer's Disease, cognition, Dementia, longevity, risk factors, risk prediction
February 2020
AI Enabled Structure and Function Analysis for Establishing the Eye as the Window to the Heart and Brain
Methods to facilitate variant interpretation in genomic sequencing
Tags: 53953, clinical data, decision support platform, genomics, Machine Learning, variant interpretation
February 2020
