Last updated Feb 21, 2019
Recently approved research (2017-2019) with the UK Biobank resource is listed below by month of data release. You can search by keyword or year. You can also enter locations and researcher names into the search box to find the results you are looking for. The chart below details research interest areas from 2012-2019, please click on the chart to enlarge it.
Approved Research
Estimating a Genetic Architecture for Hereditary Vascular Lesions Using the UK Biobank
Tags: 53312, automated phenotype, cardiovascular disease, common variation, rare disease genetics, vascular dysplasia
January 2020
Identifying genetic predictors of response to pharmaceutical drugs using machine learning
The role of rare genetic variants in the genetic architecture of complex phenotypes
Role of lifestyle-related behaviors in mediating genetic susceptibility to obesity
The interaction effects of early life exposures and genetic susceptibility on human metabolomics and common metabolic diseases
Tags: 55858, common metabolic diseases, early life exposures, genetic variants, metabolomics signatures, Obesity-related-cancers
January 2020
Machine learning for rare disease pattern recognition and analysis
Tags: 54218, clinical decision support, electronic health records, Machine Learning, pattern recognition, rare disease, statistical-inference
January 2020
Human Blood Microbiome
Validation and comparative analysis of novel prediction models focussed on modifiable lifestyle factors for the risks of common, preventable diseases and all-cause mortality: a cohort study
Optimisation of colorectal cancer prevention strategies by identification of risk factors for proximal colon cancer
Predicting Susceptibility to Cirrhosis and Liver Transplantation using Machine Learning Algorithms
The dilemma of human childbirth and the pelvic floor: A biomechanical approach
Risk factors for chronic pain
Tags: 49572, chronic fatigue syndrome, Chronic pain, diabetic neuropathy, headache, muskuloskeletal pain, neuropathic pain
January 2020
Trans-ethnic GWAS meta-analysis and exploration of trait-relevant genetic architecture
Relationship inference and its application to linkage and IBD mapping in the UK Biobank samples
Comparison of HLA imputed genotype of the general population versus population with incidence of cancer
Body composition, genetics, and bone outcomes
Estimating causal links between habitual caffeine consumption and objective measures of sleep quality in the general population
A Scale for Your Liver – Estimating Liver Fat Percentage with Accessible Measurements
Experimental-like UK Biobank Subsamples
Testing and development of diffusion MRI measures for assessing variation in brain structure and for improved detection of disease
Genomic analysis of potassium regulation by the skeleton
Exome sequence analysis of endometriosis
Segmented Analysis of Whole Genomes
Exploration of tSNE and DBScan for the identification of patient subpopulations in Electronic Health Records using International Classification of Disease (ICD)codes
Exposure to biomedical, lifestyle, socioeconomic and mental health risk factors and association with long-term health outcomes using traditional statistical and machine learning approaches
Multi-morbidity in Chronic Lung Disease: Using GWAS and Mendelian Randomization to establish causality
Data-driven identification of a drug’s disease-modifying potential outside its main indication area
Discovery of skeletal and non-skeletal phenotypic characteristics in the UK population using genetic variants identified from musculoskeletal cases in the 100,000 (100K) Genomes Project
Learning models for predicting lab values from genetic data
Identifying novel high-impact rare disease-causing mutations, genes and pathways in inflammatory bowel disease patients
Identification of genetic loci associated with skin diseases using an improved GWAS methodology, and discovery of novel therapeutic targets
Understanding the haemodynamic determinants of hypertension in UK Biobank
Mechanistic Basis for Cardiac Arrhythmias: Translating Insights from Animal Models to Human Genetics
Common risk factors and mechanisms in cardiometabolic diseases and neurodegenerative diseases
Classification of asthma patients and identification of group-specific genetic variants
Identification of common genetic modifiers of risk of vestibular schwannoma
Effective disease age of onset assessment for individuals that are carriers of variable penetrance genes, using machine learning methods
Software for Heart Chamber Segmentation and Characterization Using MRI
Identifying prevention targets for dementia in genetically stratified population subgroups
Genome-wide polygenic scores for Alzheimer disease and Parkinson disease identify individuals with risk equivalent to monogenic mutations
Comparative genetic and analysis of pulmonary diseases across different races
Application of polygenic methods to investigate shared and unique genetics across psychiatric traits including bipolar disorder, depression and substance use disorders
Altered connectivity between the two brain hemispheres in the depressive personality
Identifying genetic variants that influence retinal development and pigmentation
Diet, metabolic/inflammatory profile and risk of obesity-related chronic conditions among participants in the UK Biobank
Validation and improvement of our Machine Learning approach to analyse interactions in your genotyping/imputation data for better Familial Hypercholesterolemia diagnostics
Tags: 36226, cardio-metabolic, cardiovascular disease, familial-hypercholesterolemia, technology
December 2019
Exploring the association between dietary variety and weight
Prediction of the tumor mutation burden and its predictive value in UK biobank cancer patients: using machine learning algorithm
Identification of genetic components underlying cerebrovascular diseases and their related outcomes
Application of deep machine learning to predict cardiovascular outcomes
Genome wide association analysis of Amyotrophic Lateral Sclerosis (ALS)
An artificial intelligence algorithm based on deep learning and molecular diagnosis for identifying ocular diseases
Large-scale decision support systems for the prediction of ageing and ageing-related disorders
Tags: 53185, ageing, Alzheimer's Disease, convolutional neural networks, MRI, neurology, prediction
December 2019
Investigation of NAFLD/NASH biomarkers and development of predictive models Using Machine Learning Methods
Mechanistic modelling of neurodevelopment, neuroplasticity, and neurodegeneration
Assessment of genotype-to-phenotype relationships for the purpose of novel therapeutic development
Building polygenic risk scores for common complex traits in populations with varying ancestry background
Identification of SNPs for Urinary Bladder Cancer
Analysis of Alpha1-Antitrypsin related comorbidities
Multiomic Deep Learning Approach for Predicting Hypertensive Disease Complications
Determination of correlations between polygenic risk scores of 40 traits and actual outcomes using 500.000 individuals
Tags: 55495, genetic profiling, genetics/genotyping, polygenic risk scores, preventive healthcare
December 2019
Genetic markers and biomarkers for age-related diseases
Genome-wide association study in chronic fatigue syndrome/ myalgic encephalomyelitis (CFS/ME) to uncover the genetic susceptibility and identify biological pathways involved
Determining the genetic and environmental aetiology of complex traits and diseases using existing and novel statistical methodologies
Phenome-wide & multi-omics delineation of the polygenic architecture of complex traits
Combining brain physiology, polygenic scores, and dietary intake patterns to better understand the causes and consequences of obesity-related diseases
Unrevealing causes and consequences of variation in gut and immune-related phenotypes
Cognitive and chronobiological markers of cancer survival
Imaging genetic analysis towards neurodegenerative disorders development
Localising clusters of pain contributors in chronic back pain with machine learning techniques
Integrating machine learning methods and statistical genetics tools to understand pleiotropy and comorbidity in the UK Biobank
Early life, adulthood, and genomic risk factors for early-onset cancers
Investigating the relationship of cognitive decline with various mental and physical health conditions
Tags: 47866, Association, Cognitive-decline, comorbidities, Dementia, featured, longitudinal, risk factors
November 2019
Sex hormones as predictors of key health outcomes in men from the UK Biobank
Respiratory difficulties in people suffering from clinical anxiety
Prevalence and determinants of subclinical cardiovascular dysfunction in pre-diabetes and diabetes
Genome-wide Association Study and Mendelian Randomization Analysis of Early-onset Cancers
Association between blood lipid fractions and cognitive performance: a Mendelian randomisation study
Enhancing resilience in psychosis through within and between-family polygenic risk scoring, Gene x Gene interactions and gene-environment (GxE) prediction models (REGENESIS)
Developing Novel, Integrated, Interpretable Deep Learning Systems for Ophthalmology
Discovering disease mechanism through integration of genomic data with clinical data using 500,000 individuals in the UK Biobank
Evaluation of a hybrid whole exome sequencing panel combined with microarray data for genotype imputation into GWAS cohorts
Investigating the relationship between physical activity, fitness, diet, and mental health
Novel Ethnicity Based Cardiovascular Risk Prediction Models Using Artificial Intelligence
Tags: 53768, artificial intelligence, cardiovascular disease, cardiovascular risk prediction, genetics/genotyping, risk prediction model
November 2019
The role of ZNF516 in embryonic development and its impact on adult life
Role of sleep and circadian rhythm in treatment efficacy of antidiabetics
Predicting unexpected care needs, cost spikes, and applicability of genetic testing in enhancing these models
Examining factors mediating the causal relationship between intelligence and Alzheimer’s disease
Predictive and integrative models for disease prevention using the UK Biobank Data
Tags: 52446, electronic health records, genetics/genotyping, integrative models, Machine Learning, phenotype, prevention
November 2019
Developing and implementing new methods for evaluating the assumptions required for Mendelian randomisation
Investigating genetic basis for causal role of adiposity with type2 diabetes, non-alcoholic fatty liver diseases, and Alzheimer’s disease
A genome-wide association study for occupational mental health
A genome-wide association study for occupational mental health
Vitamin D loci and colorectal cancer risk
The healthcare utilisation and costs associated with prolonged sedentary behaviour and inactivity in UK adults
Study on the relationship between diet and cancer
Effect of economic, maternal, psycho-social, and health behavior factors, genetic susceptibility on pregnancies adverse outcomes
SCaRLeT: Sex differences in Cardiovascular Risk across Life course Transitions
Risk factors for cardio-renal syndrome
The Virtual Brains of UK Biobank
Predicting the conversion of minor cognitive impairment to dementia using default mode network and convolutional neural network
Prediction of complex phenotypes and diseases from personal genomic data and health data using machine learning
Diagnosis and treatment of urinary incontinence and prolapse
Novel, refined and integrated phenotypes to decipher the genetic component of cardiovascular disease
Medical Device use, effectiveness and safety: a multifaceted approach
Identifying the regulators of clonal hematopoiesis of indeterminate potential (CHIP)
Improving multi-contrast cardiac MRI quantification using transfer/incremental learning from cine images
Machine learning analysis of psychiatric diseases
Tags: 51709, bioinformatics, common variant, featured, genetics/genotyping, interaction, psychiatric diseases, rare variant
November 2019
Epistasis analysis of cancer susceptibility
Association of nutrient composition with metabolic syndrome and cardiovascular risk – Findings from the UK Biobank
Tags: 53438, biomarkers, cardiovascular disease, diet, metabolic-syndrome, mortality, nutrient-composition
November 2019
Genetic validation of cardiovascular drug targets with a focus on heart failure disease
Understanding successful ageing in women: how do socioeconomic and cultural factors shape diversity in menopause experience?
Development of an algorithm to classify Primary Care Electronic Health Records of alcohol consumption in Scotland
Identification of high-risk HLA Haplotypes among individuals with Type 1 diabetes in the UK Biobank population
Prediction of multi-biomarkers for various diseases using deep learning platform
Stratification and modelling of competing risks in cardiovascular disease events based on multi-level patient characteristics and genetics
Finding common brain changes and shared risk factors in early dementia, depression and concussion
Dietary determinants of hearing loss. A multi-approach project to address the impact of diet on healthy aging
Genetic, environmental and clinical determinants of blood pressure, kidney health and disease
Controlling Structure Induced Variations in Non-Invasive Perfusion MRI of Neurodegeneration
Identification of infections causally implicated in heart disease incidence and progression
Deciphering complex traits – phenotypic and genetic associations between traits in the UK Biobank Cohort
Tags: 54803, association study, brain imaging, Complex Traits, cross-trait analysis, heritability
November 2019
Systematic identification of genetic associations with drug-induced adverse reactions
Modeling genetic variation, gene expression and neuroimaging phenotypes to inform the etiology of psychopathology
Using molecular and genetic epidemiological approach to dissect the mechanism of complex diseases in the UK Biobank
Epidemiology and genetics of non-communicable diseases in South Asians
Machine learning towards early prediction and diagnosis of Autism Spectrum Disorder (ASD) and Cognitive Function
Quantitative genotype-phenotype prediction using deep probabilistic models to integrate standing human genetic variation and variation across all of evolution and clinical datatypes
Predictive Models of Mortality Risk from Passive Monitors measuring Physical Activity
Latent phenotypes of impulsivity
Reproductive patterns and ageing rate diversity
Developing a look a like model for the prediction of premature mortality and chronic disease
Human genomics of humoral immunity and chronic inflammation: searching for predictors of complex diseases
Multi-modal machine learning risk models for cardiovascular disease
A multiscale genotype – phenotype map
The association between sociodemographic variable and disparities in burden of chronic obstructive pulmonary disease in UK
Effective risk prediction and classification for complex diseases across global populations
Development of Personalised Screening Models for Melanoma and Breast, Colorectal and Prostate Cancers
Bioinformatics methods for the genetic analysis of infectious diseases
Bioinformatics methods for precision cardiovascular medicine
Genome-wide association studies to screen genetic loci linked with various infectious disease antigens
Progression patterns of disorders in multiple myeloma disease family
Sarcopenia in chronic kidney disease and diabetes mellitus: a UK Biobank study
Causal associations of novel and established risk factors with type 2 diabetes, kidney disease, lung disease and cardiovascular disease in UK Biobank
Analysis of rare variants in immune-related genes associated with clinical outcomes in neurodegeneration and cancer
Tags: 52361, allelic-series, biomarkers, disease-progression, Mendelian randomization, PheWAS
October 2019
Predictors of liver disease progression and mortality
Deep Learning Model to Predict Physiological Ageing Rate
Integration of Functional Genomics Towards Future Precision Health
Identifying Biomarkers and Biotypes for Mental Health Conditions
Designing a Screening Program for Non-alcoholic Fatty Liver Disease in the Primary Care Population
Tags: 50689, clinical prediction model, diabetes, Liver, non-alcoholic fatty liver disease, obesity
October 2019
Phenome-wide association study of variants in developmental pathway genes
Tags: 49852, drug-discovery, embryonic development, genome, phenome, PheWAS, target validation
October 2019
Role of adipose tissue distribution in abdominal and lower body compartments for metabolic health status in normal weight and obese individuals in the UK Biobank imaging cohort
An examination of the association between germline genetic polymorphisms and urinary bladder cancer survival
Clustering of cardiometabolic risk factors and their association with physical activity and sedentary time in women with and without polycystic ovary syndrome: a principal component analysis
Genome-wide association studies of alcohol dependence and substance-misuse
Exploring the genetic landscape of ATP7B and the relationship between genetic prevalence and point prevalence of Wilson Disease
Discerning Alterations in Magnetic Resonance Imaging of the Brain and Ocular Coherence Tomography in Diabetes
Tags: 45184, cognition, diabetic neuropathy, mri brain imaging, neurodegeneration, ocular coherence tomography, retinal nerve fibre layer
October 2019
Uncovering genetic and biological causes of ocular diseases and traits through integrative analysis of genetic, functional genomic, clinical, and ocular imaging data
Identification of novel risk variants associated with metabolism and type 2 diabetes
Phenome and genome wide association analysis to explore sexually-dimorphic phenotypes
Predictive Models for Cardio-Metabolic Disease: a Machine Learning Approach
Identification of genetic and lifestyle risk factors of unhealthy brain ageing to direct mechanistic studies using post-mortem brain tissue
Neuroimaging-based prediction of brain age and cognition
Copy number variation from whole exome sequencing in the UK Biobank
Role of inflammasome-driven inflammation in cardiovascular diseases
Vegan, vegetarian and omnivore dietary patterns – their impact on the metabolic profiles, body composition and cardiovascular health: A nutri-genetic exploration
Machine learning for Alzheimer’s disease
Genetic basis of adverse drug reactions
Development of statistical methods to discover novel genetic associations, explain underlying biological mechanisms, and develop risk prediction models across varied complex diseases
Understand Alzheimer’s disease characterized by brain imaging phenotype
Role of endocrine factors in cognitive and brain aging
Identifying genetic factors for brain ageing
Evaluating the effects of coding variation in inflammatory genes in cardio-metabolic disease
Development of a Novel Deep Learning Algorithm to Detect Cardiac Arrhythmias from Electrocardiogram Signals
Understanding the role of blood pressure in vascular and non-vascular diseases
Using Mendelian randomization to infer health effects of cardiovascular and diabetes medication in the UK Biobank
Neuroinflammatory biomarkers of depression and its neurobiological underpinnings
Screening and evaluation of causal relationships of cardiometabolic, psychological, and neurological traits with osteoporosis
Comprehensive study of genome-phenome associations in complex diseases and comorbidities in multi-ethnic populations
Prevalence, causes, risk factors and outcomes of intracranial haemorrhage in the UK Biobank cohort
Association of male infertility genotypes on mortality, cancer, and cardiovascular disease
OPTIMAT: Population-level Imaging, genomic and phenotypic analyses to determine how bone marrow adiposity impacts human health
Tags: 48697, bone marrow adipose tissue, featured, GWAS, Machine Learning, Mendelian randomisation, MRI, PheWAS
September 2019
Associations of oral and gut microbiome-related exposures with cancer risk and mortality
Tags: 52576, antibiotics, cancer, gut microbiome, mortality, Oral health, periodontal disease
September 2019
Genetics of diseases of ageing including osteoarthritis
Investigate associations between magnesium status and multiple clinical outcomes using MR-PheWAS
Biology and the tendency to engage in entrepreneurship
Deciphering the impact of built and atmospheric environment on mental and cognitive health, dementia and mortality outcomes utilising the UKBUMP database: a DPUK supported study
The genetic landscape of complex diseases/traits – Exploring genetic risk scores to identify shared genetics and functional pathways
GWAS and genetics study of end stage renal failure and cystic kidney disease
Polygenic and Omnigenic Phenotype Risk Prediction with Machine Learning
Polygenic Risk Score Knowledge Base
Investigating the myelodysplastic origins of Acute Myeloid leukaemia
The effect of demographic factors on our polygenetic chance of education and well-being
Elaboration and validation of prediction models for chronic disease risk based on genomic, health and medical record data
Multi-Omic Characterization of Common Disease States through Polygenic Modeling
Physical measurement, blood biochemistry, lifestyle, environmental exposure: causality, gene-environment interaction in relation to metabolic diseases and cancer risk.
Gene Based Polygenic Prediction of Adverse Drug Reactions
Evaluating the impact of computational and experimental measures of rare variant deleteriousness on burden-based association testing
Trajectories of Cognitive performance and Traumatic Brain injury
A multi-polygenic score of clock resilience and its utility in predicting vulnerability to night work with regards to chronic disease risk (cardiovascular disease, type 2 diabetes, depression, breast)
Integrative Multi-Omics to Identify Novel Therapeutic and Biomarkers for Respiratory Diseases
Genetic association and gene-environment interaction with smoking for lung cancer
Genomic data as a personalized medicine approach to evaluate the risk of chronic diseases and their public health implications
Social environments, social relationships, human genomics and health and other social outcomes
Deep phenotyping of patients with a range of chronic pain conditions in the UK Biobank using a machine-learning approach.
Population Stratification in Risk Prediction Models
Neuroanatomical, neurofunctional and genetic correlates of eating disorders – A transdiagnostical approach
Genetic and environmental factors including nutritional and lifestyle influences on neurodevelopmental disorders/traits (including impulsivity/compulsivity) and their brain correlates
Study of molecular and genetic factors for breast cancer
Polygenic risk scores for risk assessment of lung cancer in the UK Biobank and China Kadoorie Biobank
Metabolism syndrome and risk of cancer
Integrate summary level data from UK Biobank into the Knowledge Portal Network (KPN), an infrastructure that integrates, interprets, and presents genetic data to spark insights into complex diseases.
Serum cardiometabolic biomarkers in relation to all-cause and cause-specific mortality
Research using UK Biobank Data to identify key parameters that effect disease states using Machine Learning and Network Sensitivity Analysis
Leveraging medical images and deep learning to characterize biological age
Investigation of dynamic functional connectivity and its relation to phenotypic and genotypic attributes in humans
Risk Factors, Biomarkers and Impact of Major Vision-Threatening Eye Diseases
Association between serum vitamin D deficiency and the risk of herpes zoster: a longitudinal UK Biobank study
Identifying risk factors for chronic musculoskeletal pain: a multifactorial approach combining brain imaging and genetics
Phenome-wide study of blood groups in the UK Biobank
Contextual data analytics for clinical decision making
The interrelationship of cardio- and neuro-vascular disease: associations with progressive brain atrophy and cognitive decline
PheWAS to support genetically-guided drug development at Eisai
Validity and performance of inherited risk assessment for common diseases using polygenic risk score, family history, and high-penetrance genes
Discovery and validation of human genetic modifiers of disease risk, severity, and progression
Dr Ian Galea
The influence of adiposity, ethnicity and anti-hypertensive medication on blood pressure, blood pressure control and cardiovascular events
Tags: 45885, adiposity, anti-hypertensives, blood pressure, cardiovascular, ethnicity, obesity
September 2019
Development of a novel activity index that predicts changes in cognitive function
Broken bones and broken hearts: relationships between osteoporosis and cardiovascular disease in the UK Biobank population
Integration of UK Biobank data to improve diagnostic yield of exomes for rare genetic disorders
The genetic basis of sex-specific fitness variation in humans
Antidepressant use and risk of morbidity and mortality: a population-based cohort study
Genetics of the comorbidities of cardiometabolic diseases
Genetic association analysis for brain imaging phenotypes in Alzheimer’s Disease
Identifying genetic tissue-specific disease risk of type 1 diabetes
Disect the genetic architecture of various sociological traits through integrative analysis of GWAS and functional annotations
The effects of social isolation on brain structure and function: relationship with depression
Detecting early imaging phenotypes of tau associated dementia in the general population
Modelling dementia risk in real-world clinical and population data
Tags: 47279, ageing, cognition, Dementia, featured, Imaging, prevention, risk prediction
September 2019
Statistical models of the shape, distribution and quantity of the tissues (adipose, muscle, bone) and it’s relations to the outer shape of the body and body composition
Tags: 51951, anatomic-atlas, body composition, human-shape, internal-from-external, Statistical models
September 2019
The relationship between pain, social exclusion, anxiety, depression and related psychological problems
Electrophysiological remodelling in patients at elevated risk of ventricular arrhythmia and sudden cardiac death
Bayesian Models for Gene and Behavioral Interaction on Cancer and Cardiovascular Morbidity and Mortality
OPTIMAT: Population-level Imaging, genomic and phenotypic analyses to determine how bone marrow adiposity impacts human health
Uncovering genetic bases across human traits and diseases
Tags: 41751, Complex Traits, disease, genetics/genotyping, health, Machine Learning, prediction
September 2019
