Last updated Nov 6, 2018
Recently approved research (2017-2018) with the UK Biobank resource is listed below by month of data release. Please click on the chart to enlarge it. You can search by keyword or year. You can also enter locations and researcher names into the search box to find the results you are looking for.
Approved Research
Daily patterns of physical activity and syndromes of ageing. Relationship between physical inactivity and markers of geriatric syndromes
Relationship between cerebral pulsatility and cognitive impairment and its mediation by small vessel disease, and the potential role of arterial stiffness
Understanding the relationship between diet, nutrition and metabolic diseases
Deep learning for predictive modelling of Alzheimer’s disease related dementia
Identification of cardiac structure via MRI for 3D printing
Boosting disease detection rate by characterizing the genetically informed normal range of biomarkers and imaging measures
The Evolutionary History and the Genetic Architecture of Complex Traits
Comparison of accelerometer-derived physical activity patterns among current cancer patients, cancer survivors, and cancer-free population
A meta-investigation of combinatorial mutation signatures in broad disease categories
Common Mental Disorder and its Correlates in UK Biobank
Study of the genetics of complex traits
Identifying and quantifying risk factors for macular disorders using automated approaches to phenotyping
Genetics and Epidemiology of Common Hand Conditions (GECHCo)
Quantifying abnormalities of haematopoietic and immune system in patients with Bardet-Biedl syndrome
Risk Stratification in Dementia
Phenome-wide association study of the C282Y mutation in HFE
Methods development for improved inference from meta-GWAS summary statistics
Pre-eclampsia and cardiovascular risk: a case-control study of genes and cardiac function
Translating genetics of nicotine dependence to pulmonary function
Biomarker profiling by NMR metabolomics for the study of chronic disease risk and underlying risk factors
Mental health risk factors and outcomes: elucidating reciprocal causal relationships
Understanding the relationships between movement and long term conditions.
Stratification of neurodegenerative disease patients using genetic architecture consisting of genomic and digital health records.
APOE-lifestyle interactions on age-related health outcomes in the UK Biobank population
Information-Theoretic Inference of Complex Multivariable Associations: Improving the Genetic Discrimination of Type 1/Type 2 Diabetes
Identification of functional germline variants in childhood cancers
Human physiological networks in health and disease
The epidemiology of infectious diseases within UK Biobank
Evaluating the utility of disease polygenetic risk scores in identifying high-risk individuals using UK Biobank data
Associations between physical activity patterns and measures of physical function in South Asians and White Europeans
The prevalence of nuclear/mitochondrial DNA interactions in the UK population
Genomic inversions, life-style and environment as joint risk factors for common complex diseases
Obesity, body shape, nutrition, hypertension, steroid hormones and vitamin D: associations, interactions and contribution to metabolic health and the risk of cancer development and survival
Discovery and characterization of the genetic contribution to kidney function
Characterising the relationship between behavioral and mental health characteristics and the modular organization of the brain network
Development of Perioperative Risk Quantification Algorithm and Intraoperative Clinical Support System using Integrated Medical History and Patient Genotype
Genomic mechanisms of genetic variants influencing risk of diabetes and diabetic complications
Genetic and environmental causes of psychotic experiences in the community in UK Biobank
Non-additive effects in control of complex human traits
Type 1 diabetes fine-mapping using related traits and meta-analyses with existing T1D data
Statistical/Machine classification of disease
Automated analysis of abdominal aortic calcification in DXA VFA images
Using genetic methods to explore etiologic hypotheses of depression
Application to Use UK Biobank Data as Part of the Psychiatric Genomics Consortium for PTSD Neuroimaging Project
Hypoxia, metabolism and their related pathways
Gene Network by environment (GnxE) study of impulsivity- methodology to extend GxE studies
Sleep as a biomarker of healthy ageing, metabolic health and cognition
Exploring the relationships of movement behaviours with adverse health outcomes
Investigating the genetic basis of four common cancers with a large pedigree resource
Understanding polygenic liability through connectome-based genetic imaging
Using MRI imaging to investigate how cardiac shape and function effect dementia-associated brain lesions and what genes and health factors underlie these changes
Burden of variants in obesity-related genes
Combined effect of the genetic and lifestyle determinants of metabolic syndrome on cardiometabolic risk
Reproductive and dietary risk factors of type 2 diabetes and cardiovascular diseases
Risk Factors and Health Consequences of Cerebral White Matter Hyperintensity
Identifying long runs of homozygosity in the UK Biobank
Understanding the Pathophysiology of Cystic Fibrosis Gene Modifiers
Genetic factors associated with Diabetic retinopathy
Genetic study of normal hearing function (NHF) and age-related hearing loss (ARHL)
Interpreting Gene Expression in the Gut-Brain Axis Through the Lens of Human Genetics
Tags: 41018, Bayesian, Brain, disease, featured, Gastrointestinal, network, systems biology
November 2018
Inflammation, depression and cardiovascular disease: examining causal associations
Tags: 26999, biomarkers, cardiovascular disease, depression, featured, genetics/genotyping, inflammation, Mendelian randomisation
November 2018
Imaging chronotype: exploring the anatomical correlates of circadian preference
Association between cardiometabolic health and cancer
Tags: 41276, cancer, cardiovascular, diabetes, Mendelian randomisation, metabolic, risk prediction
October 2018
Blood pressure and bladder cancer risk by use of conventional analysis of main effects and in interaction with the NAT2 genotype, and by Mendelian randomization analysis
Cancer risk and cancer outcomes among sexual minorities compared with heterosexual men and women
Investigating rare genetic drivers of bone mineral density
Machine learning to predict outcomes from cardiac imaging
Assessing the effect of free water on brain microstructure in aging using diffusion MRI
Quantitatively understanding how bone mineral density varies with age and disease using DXA Region Free Analysis
Method development and analysis of biobank imaging, behavioral and genetic data
Identification of Prostate Cancer Susceptibility Loci by Meta-analysis of Multi-ethnic GWAS and Predicting Prostate Cancer Risk with Polygenic Risk Scores
Determining the effects of objectively-measured physical activity on circuit-specific brain aging in a massive multi-modal neuroimaging community sample
Evaluation of deep learning in capturing epistatic effect
Understanding the genetic architecture of human brain shape from MRI using global-to-local shape segmentations
Studying the human brain mosaic
Investigating aetiology, associations and causality in diseases of the head and neck
Non-reproductive effects of endogenous androgen exposures, potential drivers of and downstream factors related to androgens: a Mendelian randomization study in the UK Biobank
The Identification of patients at risk in screening for sporadic pancreatic cancer
Gene-Environment interplay in psychosis
Multimodal Data Analysis to Identify Biomarkers and Patient Cohorts in Neurodegenerative Diseases
Genetic determinants of human reproductive traits
Detecting pleiotropic effects through integration of omics data
Rare deleterious CNVs share some overlapping effects on brain structure
Genomic analysis of severe outcomes to acute respiratory infection
Sex-specific Genetic Determinants of Cardiometabolic Traits
Germline prognostic markers and gene-environment interaction with smoking for urinary bladder cancer
Chronic Pain in Shiftworkers: the Role of Sleep, Circadian Rhythms and the Autonomic Nervous System
Quantifying the role of linkage disequilibrium in mapping genetic regions within and across traits.
A convolutional neural network classifier for gender classification
Dementia use case for ‘iASiS’ platform
Building Machine Learning Models for Breast Cancer Risk Prediction
Genetic substrate of valvular heart disease and its arrhythmic complications
Identifying precision drug treatments by linking phenotype and genotype in drug response
Sex and sexual orientation-related differences in brain structure: associations with victimisation, mental health outcomes and biomarkers
Identification of novel rare genetic variants associated with COPD in the general population
Influence of plasma lipoprotein genetics on infectious disease outcomes
The cognitive footprint of medication: Evaluation and recommendations based on the UK Biobank cohort
A retrospective investigation of accelerometer-derived movement patterns, with the aim of validating a machine learning algorithm, and potential identification of novel signs of disease
GWAS of tinnitus and hearing loss in the general population with emphasis on noise exposure and aging
Phenome environment wide interaction study
Genetic studies of hearing-related traits
Analysis and computational method development towards unravelling and better understanding genetic variation underlying cardiovascular and haematological complex traits
Application of deep neural networks to human ageing biomarker development
Retinal Vasculature Representation Learning for Computational Biomarker Discovery
Statistical methods for discovery and validation of associations with cardiovascular and aging traits and their associated risk factors
Tags: 42614, aging, cardiovascular, featured, genetics/genotyping, Polygenic, risk factors, statistical methods
October 2018
Melatonin, lifestyle, and health: a gene-environmental investigation in the UK Biobank
Tags: 43015, cancer, cardiovascular, diabetes, featured, genetics/genotyping, lifestyle, melatonin
September 2018
Designing a resampling approach to control for population stratification in rare variant association tests
Interaction between physical activity, obesity and cardiovascular risk factors in modulating risk of arrhythmias
Omega-6 fatty acids, FADS1/2 genetic variants, and breast cancer risk: A Mendelian Randomisation Study
Define disease endotypes agnostic of conventional diagnostic classes
Exploring the relationship between body weight and cognitive functions across the lifespan using deep learning techniques
Application of Imiomics to whole-body MRI data for creation and application of a human imaging atlas
Tags: 14237, aging, body composition, cardiovascular disease, genetics, imiomics, Mendelian randomization
September 2018
Optimising neuroimaging biomarkers of brain ageing to identify genetic and environmental risk factors for poor brain health
iSTAGING (Imaging-based coordinate SysTem for AGing and NeurodeGenerative diseases)
Statistical genetics methods for complex traits using large-scale genomic data
SmartHeart: Next-generation cardiovascular healthcare via integrated image acquisition, reconstruction, analysis and learning
Application of deep learning for the characterisation of motion patterns in the heart
Dementia risk in South Asians: data from the UK
Phenotypic annotation of common SCZ risk variant combinations
Study of the genetic basis of mitral valve prolapse using meta-analysis of GWAS
Comparison of different genetic modeling methods for complex genetic conditions
Investigating the Aetiology of Oesophageal and Gastric Cancers:The Role of Hormones
Magnetic resonance image properties of the substantia nigra and other brain regions among smokers
Phenome-Wide Association Studies to inform therapeutic development at Novartis Institutes for Biomedical Research
Cardiovascular medication use for the primary and secondary prevention of cardiovascular disease in the UK: trends, determinants and lifestyle behaviours
On the genetic and environmental intersection of mental and physical health
Genetic heterogeneity of respiratory disorders
Predictors of successful cognitive ageing and well-being: impact of sleep, physical activity and neuromodulators on age-related changes in frontoparietal connectivity
Comprehensive genome-exposome-phenome association studies for complex diseases
Construction of Multi-dimensional Statistical Shape Model for a heart
Genetics of complex diseases, comorbidities, and other traits in multi-ethnic samples
Risk and protective factors for MRI markers of cerebral small vessel disease
Validation of heritability estimation software and subtyping algorithms in stroke, epilepsy, and Chronic Obstructive Pulmonary Disease (COPD) using UK BioBank electronic health record and genomic data
Efficient Gene-Environment Interaction Tests in Large Samples
Brain anatomy and substance use
Leveraging UK Biobank data to inform on genetics of epilepsy, psychosis and complications in kidney transplant
Genetic determinants of breast cancer prognosis and aggressivity – a phenome-wide association study
Exploring the effects of genome structural variation on human health and disease
Topic Modeling for Phenomewide Studies in Biobanks
Genetic analyses of age-of-onset in cerebral small vessel disease
Examining the causal relationship between health outcomes and socioeconomic status through Mendelian Randomization.
Statistical Method Development for Phenome-Wide Association Studies
Validating risk prediction equations for common cancers as possible tools to direct risk-adapted screening and prevention: a cohort study using the UK Biobank
Validating genomic trait prediction algorithms for commercial use with the UK Biobank resource
Identification of gene-environment interactions and causal pathways for obesogenic cardiometabolic diseases
Estimate the causal effect of asthma on risk of obesity using Mendelian randomization
Understanding the role of diet and lifestyle on obesity, cardiovascular health, cancer, mental health and cognitive function
Activity data as an input to EPSRC funded project ‘The Wearable Clinic: Connecting Health, Self and Care’
Associations between air quality, regional brain volumes, cognitive functioning, and neuropsychiatric outcome in middle-aged and older adults: a cross-sectional study
Tags: 41535, air pollution, bipolar disorder, brain morphology, cognition, depression, featured, neurodegeneration
August 2018
Thyroid Dysfunction and Women’s Cancer Risk
Gene-Environment Interplay in the Generation of Health and Education Inequalities (GEIGHEI)
Association tests for structured and multimodal data
Development and validation of a risk prediction model for oesophageal squamous cell carcinoma using cohort studies
Myeloproliferative neoplasms and clonal haematopoiesis
Developing Statistical Methods for Genetic and Imaging Studies of Substance Use and Dependence
Understanding the dose-response relationships between modifiable lifestyle behaviors & environment with chronic disease risk and mortality: Creating simple tools for improving public health
Refining polygenic score performance in diverse populations
The role of diabetes and glycemic traits in diabetic bone disease, utilizing both traditional and molecular epidemiological methods.
The association of sex steroid hormone levels with cancers of the pancreas, kidney, and brain in the U.K. Biobank
Understanding the biological, lifestyle and environmental risks and outcomes for multimorbidity in psychiatric disorders
Prediction models of health and wellness traits based on genetics, anthropometric, and clinical data
Low LDL cholesterol and mortality
Predictive Modeling of Age-related Macular Degeneration with Multimodal and Interpretable Convolutional Neural Networks
Method development and analysis of biobank imaging, behavioral and genetic data
Interstitial lung disease and Idiopathic pulmonary fibrosis, quality of life and physical activity
Workplace exposure to airborne particles and the association with diabetes and dementia in a large population cohort study
Tags: 42084, air pollution, airborne particles, cognition, Dementia, diabetes, featured, occupational
August 2018
Discovering the biological mechanisms underlying glaucoma and neurodegeneration by analysis of genetic and environmental determinants and associations with other systemic traits in the UK Biobank
Multimorbidity and dementia: an observational cohort study using the UK Biobank
Genetics of Vegetarianism
The genetic study of osteosarcopenic obesity
The role of serum-based small molecule antioxidants in preventing and predicting age-related phenotypes and respiratory cancer
Integrated predictive risk models using multimodal imaging and genetics
Tags: 35667, Computer Vision, deep learning, featured, longitudinal, multi-modality, prediction, whole-genome-sequencing
July 2018
Gene and environment association studies in HUNT and UK Biobank
Risk factors for cardiovascular disease in people with schizophrenia
Mediating mechanisms linking anthropometric, lifestyle and dietary risk factors with cancer risk
Development of a computational method to predict disease risk
Major risk factors for Cardiovascular Disease
Predicting longitudinal outcomes in chronic obstructive pulmonary disease
The role of cardiorespiratory fitness and physical behaviours in protecting against premature mortality
Dr Qing Lu, Developing Statistical Methods for Genetic and Imaging Studies of Substance Use and Dependence
Tags: 40967, Complex Traits, featured, GWAS, Imaging, neural network, substance dependence, substance use
July 2018
Dr Johan Verjans, Phenotyping cardiovascular disease using deep learning: Correlation of medical images, biomarkers and genetics to clinical outcome
Professor Melinda Mills, Exploring Selection in the UK Biobank
Professor Melinda Mills, Non-standard employment schedule resilience: A multifactorial approach
Dr Thomas Rohan, The association of type 2 diabetes and HbA1c with subsequent risk of cancer at different anatomical sites
Dr Laufey Amundadottir
Dr Samuel Mathias, Genetic and environmental risk factors for hearing difficulties
Dr Thomas Rohan, Body fat composition and risk of obesity-related cancers among adults with normal body mass index in the UK Biobank cohort
Dr Thomas Rohan, Interplay between lifestyle factors, genetics and risk of breast cancer among UK women
Dr Ryan Amelon, Classification and automatic detection of OCT layer segmentation failure modes
Tags: 41044, Convolutional-Neural-Network, deep learning, Failure-Modes, featured, Image-Quality, Layer-Segmentation, OCT
July 2018
Dr Matthew Robinson, Improving estimation and prediction of common complex disease risk
Tags: 35520, cardiovascular disease, Complex Traits, featured, genetics, metabolic-disease, psychiatric, risk factors
June 2018
Dr Guoying Yu, Assessment of rare variants of Mendelian genes in association with traits and/or disease phenotypes in UK Biobank
Future risk of cancer and cardiovascular disease in women who experience a hypertensive disorder of pregnancy, and its modification by a common, functional, IGF1R
Professor Simon Baron-Cohen, Genetic and phenotypic investigation of neural brain network connectivity
Professor Thomas Ploetz, Learning a Lexicon of Human Movements: Automated, data-driven detection of elementary movement units for objective, accurate and interpretable analysis of physical activities and human behavior
Dr Bevan Huang, Machine learning of disease incubation signatures
Professor Christian Wachinger, Joint analysis of abdominal and cerebral morphology in diabetes
Ultra-processed foods consumption and health markers in UK BioBank
Professor Darren Ashcroft, Examining the characteristics of patients with psoriasis and its association with major comorbid conditions: cross-sectional study
Dr Steven van der Werff, Neural characteristics of resilience to traumatic stress
Dr Susan Hodgson, Natural Environments and Wellbeing in the UK
Dr Andrea Mechelli, Using deep learning technology to make individualised inferences in brain-based disorders
Tags: 40323, Brain disorders, clinical-tool, deep learning, neuroimaging, normative-model, translational-approach
June 2018
Professor Suzanne Leal, Identification of genetic risk factors for age-relating hearing disorders
Dr Mindie Nguyen, Interaction between metabolic syndrome and other environmental, genetic and clinical factors impacting liver disease and other health outcomes
Dr Ashley Webb, Association between FOXO3 genetic variants and cognitive performance in aged individuals
Dr Yan Gong, Pharmacogenomic Genome-wide Association Analyses of Drug Responses and Adverse Events Using UK Biobank Data
Dr Aldo Faisal, BioBank Behavioural BioMarkers (B4M)
Professor Daniel Chasman, Genetic analysis of peripheral artery disease and migraine
Professor Masud Husain, The effects of age, sex, genotype and systemic health on brain structure and function
Dr Patrick Gladding, A Mendelian Randomisation Study to Assess the Interaction between ADCY9 rs1967309, HDL, Diet and Atherosclerosis Measured by Carotid Intima Media Thickness (CIMT)
Professor Alon Keinan, Novel methods for detecting single-marker associations, gene-gene and gene-environment interactions, with a focus on the X chromosome
Professor Paul Brenchley, Interaction of genetics and environment in triggering anti-PLA2R autoantibody in membranous nephropathy: a paradigm for initiation of autoimmunity
Dr Alain Dagher, From predictors to obesity and vascular factors: the mediating roles of cognition, affect, brain structure and function
Mr Matias Fuentealba, Discovering new drug targets to improve health during ageing
Dr Diana van Heemst, Thyroid signalling and common age-related diseases: a Mendelian Randomisation study and thyroid pathway analysis
Professor Emmanuel Stamatakis, Integrated paradigms to investigate the interplay between lifestyle behaviours, the social environment, and genetic risk in the development of cardio- metabolic disease and mental health
Dr Peter Sorensen, Genomic feature prediction models
Tags: 31269, prediction
