Last updated Feb 21, 2019
Recently approved research (2017-2019) with the UK Biobank resource is listed below by month of data release. You can search by keyword or year. You can also enter locations and researcher names into the search box to find the results you are looking for. The chart below details research interest areas from 2012-2019, please click on the chart to enlarge it.
Approved Research
Understanding the genetic architecture of chronic liver disease
Discovery and validation of genetic biomarkers to stratify patients with psychiatric disorders based on cognitive impairment
Tags: 43592, cognitive impairment, drug-discovery, eqtl, genotype biomarker, schizophrenia
February 2019
Causal Inference in Large-Scale Clinical Neuroimaging Studies
The association of genomic variation, exogenous female hormones, and statin therapy with the risk of incident and recurrent arterial and venous thrombosis
Deep-Learning based Multiclass Retinal Fluid Segmentation and Detection in Optical Coherence Tomography Images using a Fully Convolutional Neural Network
Systematic identification into the genetic basis of malignancies affecting the upper gastrointestinal tract
Mendelian Randomization to Determine the Attributable Healthcare Cost of Obesity
Rare, functionally validated, nonsense and missense mutations and human anthropometric and metabolic traits
Single nuclear polymorphisms in PIEZO1 gene and Cardiovascular Diseases
Quantifying genomic differentiation between the sexes: implications for sex-specific health and infertility
Incorporating Biomarkers in Social Science Research on Healthy Ageing: An Intersectionalities Approach
Harmonising large-scale imaging databases to provide integrated assessments of the role of white matter hyperintensities in cognitive aging
Survey of Genetic Factors Affecting Disease Risk and Progression
Genetic effect and genetic correlation among multiple related phenotypes and interaction with environmental exposures
The use of commonly prescribed medications and survival in cancer patients
Genome-wide assessment of gene-smoking interactions on lung function
The role of epitope-binding features of HLA alleles in health and disease
Explore the associations between different exposures and health outcomes
Interactions between Sugar Consumption and Genetic Variation on Cardiometabolic Traits
CARDIOMARKER- Computational imaging phenomics in population cardiac MRI with automatic image quality assessment: benchmarking, scalability and inference with state-of-the-art algorithms
A Machine Learning based screening system for Retinal and Systemic Diseases
Causal relationships between environmental exposures and risk of human cancers: a phenome-wide mendelian randomization analysis
Multi-Modal Analysis of the UK Biobank Neuroimaging Data
Develop biomarker of chronic fatigue syndrome (CFS) from accelerometer data
Genomic Data Analysis using Machine Learning Methods for Disease Classification and Causal Gene Analysis
Scalable and Robust methods for biobank data analysis
Environmental and clinical correlates of medical comorbidities in severe mental illness
Novel methods for the use of hierarchically-structured healthcare data in genetic association analyses
Do childhood circumstances predict later life loneliness?
Tags: 44521, adverse childhood experiences, child health, featured, loneliness, social isolation
January 2019
Is sleep associated with cognitive and psychosocial outcomes in autism spectrum disorder?
Cancer risk of FADS1 haplotypes
Pathological Brain Ageing in the General Population – Effects from Trauma, Depression and Genetics
Risk factors for intracerebral and subarachnoid haemorrhage in the general population
Novel ECG measures of electrophysiological substrate
Advancing actigraphy-based daily activity and sleep analysis with machine learning to understand baseline biometrics in healthy individuals and those experiencing various medical conditions
Building and evaluating multivariate statistical machine learning methods for knowledge extraction from the UK Biobank
Genetic variability associated with shift work tolerance
Tags: 40732, chronotype, Insomnia, Night work, shift work, Shift work tolerance, sleep duration
December 2018
The inverse link between incidence rates of cancer and Alzheimer’s disease: comparing spurious and causal explanations to illuminate the causes of Alzheimer’s disease
The relationship between densities of different types of food outlets and adiposity measures in UK adults
Stratifying Psychosis Using BioBank
Identifying coincident drugs that alter headache progression and remission
Automatic Assessment and Quantification of Cardiovascular MRI exams
SNP-Biomarker Interactions in Blood Pressure Regulation
Associations between sleep and cognition in middle-aged and older adults: mediating effects of demographic and mental health factors and resting state brain-connectivity
The association between milk and dairy products and the risk of major diseases and all-cause mortality: a Mendelian randomisation study using UK Biobank
Exploring human proteases as new therapeutic targets
Exploring the genetic basis of inhibition in the brain
Investigating genetic predisposition for heart valve dysfunction
Low-density lipoprotein cholesterol (LDL-C) polygenic risk score and whole exome sequencing to diagnose individuals affected by familial hypercholesterolaemia
Functional significance of noncoding human mutations
The Neuropsychological Consequences of Coeliac Disease
Protecting the Aging Brain: Self-Organizing Networks and Multi-Scale Dynamics Under Energy Constraints
Investigation of the epistatic effects between the mitochondria, the Y-chromosome, and the nuclear genome in relation to health-related traits
Exploring the role of diet in mental illness, cognition, and multiple sclerosis
The role of commonly used medications and supplements in cancer prevention and survival
Investigating the genetics of congenital, age-related and environment-induced hearing loss
Modeling Brain Connectivity in Relation to Cognitive Decline
Investigating incomplete penetrance and the genetic architectures of human traits and diseases
Genetic factors as a biological link between food intake and cognition
Gene-Environment Interaction and Occupational Well-Being
Impact of genetic and environmental associations on neuropsychiatric disorders and associated phenotypes
Causes of biliary tract cancers: evidence from prospective observational studies, genome-wide association analysis and mendelian randomization
Mendelian randomization study to asses causal link between osteoporosis and other autoimmune and chronic diseases
Data-integrative approaches to comorbidity in mental disorders
Genetic and non-genetic factors able to predict and modify the risk of different types of cancer
Set-based association testing, construction of SNP-based prediction models and estimation of rare SNP heritability
Daily patterns of physical activity and syndromes of ageing. Relationship between physical inactivity and markers of geriatric syndromes
Relationship between cerebral pulsatility and cognitive impairment and its mediation by small vessel disease, and the potential role of arterial stiffness
Understanding the relationship between diet, nutrition and metabolic diseases
Deep learning for predictive modelling of Alzheimer’s disease related dementia
Identification of cardiac structure via MRI for 3D printing
Boosting disease detection rate by characterizing the genetically informed normal range of biomarkers and imaging measures
The Evolutionary History and the Genetic Architecture of Complex Traits
Comparison of accelerometer-derived physical activity patterns among current cancer patients, cancer survivors, and cancer-free population
A meta-investigation of combinatorial mutation signatures in broad disease categories
Common Mental Disorder and its Correlates in UK Biobank
Study of the genetics of complex traits
Identifying and quantifying risk factors for macular disorders using automated approaches to phenotyping
Genetics and Epidemiology of Common Hand Conditions (GECHCo)
Quantifying abnormalities of haematopoietic and immune system in patients with Bardet-Biedl syndrome
Risk Stratification in Dementia
Phenome-wide association study of the C282Y mutation in HFE
Methods development for improved inference from meta-GWAS summary statistics
Pre-eclampsia and cardiovascular risk: a case-control study of genes and cardiac function
Translating genetics of nicotine dependence to pulmonary function
Biomarker profiling by NMR metabolomics for the study of chronic disease risk and underlying risk factors
Mental health risk factors and outcomes: elucidating reciprocal causal relationships
Understanding the relationships between movement and long term conditions.
Stratification of neurodegenerative disease patients using genetic architecture consisting of genomic and digital health records.
APOE-lifestyle interactions on age-related health outcomes in the UK Biobank population
Information-Theoretic Inference of Complex Multivariable Associations: Improving the Genetic Discrimination of Type 1/Type 2 Diabetes
Identification of functional germline variants in childhood cancers
Human physiological networks in health and disease
The epidemiology of infectious diseases within UK Biobank
Evaluating the utility of disease polygenetic risk scores in identifying high-risk individuals using UK Biobank data
Associations between physical activity patterns and measures of physical function in South Asians and White Europeans
The prevalence of nuclear/mitochondrial DNA interactions in the UK population
Genomic inversions, life-style and environment as joint risk factors for common complex diseases
Obesity, body shape, nutrition, hypertension, steroid hormones and vitamin D: associations, interactions and contribution to metabolic health and the risk of cancer development and survival
Discovery and characterization of the genetic contribution to kidney function
Characterising the relationship between behavioral and mental health characteristics and the modular organization of the brain network
Development of Perioperative Risk Quantification Algorithm and Intraoperative Clinical Support System using Integrated Medical History and Patient Genotype
Genomic mechanisms of genetic variants influencing risk of diabetes and diabetic complications
Genetic and environmental causes of psychotic experiences in the community in UK Biobank
Non-additive effects in control of complex human traits
Type 1 diabetes fine-mapping using related traits and meta-analyses with existing T1D data
Statistical/Machine classification of disease
Automated analysis of abdominal aortic calcification in DXA VFA images
Using genetic methods to explore etiologic hypotheses of depression
Application to Use UK Biobank Data as Part of the Psychiatric Genomics Consortium for PTSD Neuroimaging Project
Hypoxia, metabolism and their related pathways
Gene Network by environment (GnxE) study of impulsivity- methodology to extend GxE studies
Sleep as a biomarker of healthy ageing, metabolic health and cognition
Exploring the relationships of movement behaviours with adverse health outcomes
Investigating the genetic basis of four common cancers with a large pedigree resource
Understanding polygenic liability through connectome-based genetic imaging
Using MRI imaging to investigate how cardiac shape and function effect dementia-associated brain lesions and what genes and health factors underlie these changes
Burden of variants in obesity-related genes
Combined effect of the genetic and lifestyle determinants of metabolic syndrome on cardiometabolic risk
Reproductive and dietary risk factors of type 2 diabetes and cardiovascular diseases
Risk Factors and Health Consequences of Cerebral White Matter Hyperintensity
Identifying long runs of homozygosity in the UK Biobank
Understanding the Pathophysiology of Cystic Fibrosis Gene Modifiers
Genetic factors associated with Diabetic retinopathy
Genetic study of normal hearing function (NHF) and age-related hearing loss (ARHL)
Interpreting Gene Expression in the Gut-Brain Axis Through the Lens of Human Genetics
Tags: 41018, Bayesian, Brain, disease, featured, Gastrointestinal, network, systems biology
November 2018
Inflammation, depression and cardiovascular disease: examining causal associations
Tags: 26999, biomarkers, cardiovascular disease, depression, featured, genetics/genotyping, inflammation, Mendelian randomisation
November 2018
Imaging chronotype: exploring the anatomical correlates of circadian preference
Association between cardiometabolic health and cancer
Tags: 42176, cancer, cardiovascular, diabetes, Mendelian randomisation, metabolic, risk prediction
October 2018
Blood pressure and bladder cancer risk by use of conventional analysis of main effects and in interaction with the NAT2 genotype, and by Mendelian randomization analysis
Cancer risk and cancer outcomes among sexual minorities compared with heterosexual men and women
Investigating rare genetic drivers of bone mineral density
Machine learning to predict outcomes from cardiac imaging
Assessing the effect of free water on brain microstructure in aging using diffusion MRI
Quantitatively understanding how bone mineral density varies with age and disease using DXA Region Free Analysis
Method development and analysis of biobank imaging, behavioral and genetic data
Identification of Prostate Cancer Susceptibility Loci by Meta-analysis of Multi-ethnic GWAS and Predicting Prostate Cancer Risk with Polygenic Risk Scores
Determining the effects of objectively-measured physical activity on circuit-specific brain aging in a massive multi-modal neuroimaging community sample
Evaluation of deep learning in capturing epistatic effect
Understanding the genetic architecture of human brain shape from MRI using global-to-local shape segmentations
Studying the human brain mosaic
Investigating aetiology, associations and causality in diseases of the head and neck
Non-reproductive effects of endogenous androgen exposures, potential drivers of and downstream factors related to androgens: a Mendelian randomization study in the UK Biobank
The Identification of patients at risk in screening for sporadic pancreatic cancer
Gene-Environment interplay in psychosis
Multimodal Data Analysis to Identify Biomarkers and Patient Cohorts in Neurodegenerative Diseases
Genetic determinants of human reproductive traits
Detecting pleiotropic effects through integration of omics data
Rare deleterious CNVs share some overlapping effects on brain structure
Genomic analysis of severe outcomes to acute respiratory infection
Sex-specific Genetic Determinants of Cardiometabolic Traits
Germline prognostic markers and gene-environment interaction with smoking for urinary bladder cancer
Chronic Pain in Shiftworkers: the Role of Sleep, Circadian Rhythms and the Autonomic Nervous System
Quantifying the role of linkage disequilibrium in mapping genetic regions within and across traits.
A convolutional neural network classifier for gender classification
Dementia use case for ‘iASiS’ platform
Building Machine Learning Models for Breast Cancer Risk Prediction
Genetic substrate of valvular heart disease and its arrhythmic complications
Identifying precision drug treatments by linking phenotype and genotype in drug response
Sex and sexual orientation-related differences in brain structure: associations with victimisation, mental health outcomes and biomarkers
Identification of novel rare genetic variants associated with COPD in the general population
Influence of plasma lipoprotein genetics on infectious disease outcomes
The cognitive footprint of medication: Evaluation and recommendations based on the UK Biobank cohort
A retrospective investigation of accelerometer-derived movement patterns, with the aim of validating a machine learning algorithm, and potential identification of novel signs of disease
GWAS of tinnitus and hearing loss in the general population with emphasis on noise exposure and aging
Phenome environment wide interaction study
Genetic studies of hearing-related traits
Analysis and computational method development towards unravelling and better understanding genetic variation underlying cardiovascular and haematological complex traits
Application of deep neural networks to human ageing biomarker development
Retinal Vasculature Representation Learning for Computational Biomarker Discovery
Statistical methods for discovery and validation of associations with cardiovascular and aging traits and their associated risk factors
Tags: 42614, aging, cardiovascular, featured, genetics/genotyping, Polygenic, risk factors, statistical methods
October 2018
Melatonin, lifestyle, and health: a gene-environmental investigation in the UK Biobank
Tags: 43015, cancer, cardiovascular, diabetes, featured, genetics/genotyping, lifestyle, melatonin
September 2018
Designing a resampling approach to control for population stratification in rare variant association tests
Interaction between physical activity, obesity and cardiovascular risk factors in modulating risk of arrhythmias
Omega-6 fatty acids, FADS1/2 genetic variants, and breast cancer risk: A Mendelian Randomisation Study
Define disease endotypes agnostic of conventional diagnostic classes
Exploring the relationship between body weight and cognitive functions across the lifespan using deep learning techniques
Application of Imiomics to whole-body MRI data for creation and application of a human imaging atlas
Tags: 14237, aging, body composition, cardiovascular disease, genetics, imiomics, Mendelian randomization
September 2018
Optimising neuroimaging biomarkers of brain ageing to identify genetic and environmental risk factors for poor brain health
iSTAGING (Imaging-based coordinate SysTem for AGing and NeurodeGenerative diseases)
Statistical genetics methods for complex traits using large-scale genomic data
SmartHeart: Next-generation cardiovascular healthcare via integrated image acquisition, reconstruction, analysis and learning
Application of deep learning for the characterisation of motion patterns in the heart
Dementia risk in South Asians: data from the UK
Phenotypic annotation of common SCZ risk variant combinations
Study of the genetic basis of mitral valve prolapse using meta-analysis of GWAS
Comparison of different genetic modeling methods for complex genetic conditions
Investigating the Aetiology of Oesophageal and Gastric Cancers:The Role of Hormones
Magnetic resonance image properties of the substantia nigra and other brain regions among smokers
Phenome-Wide Association Studies to inform therapeutic development at Novartis Institutes for Biomedical Research
Cardiovascular medication use for the primary and secondary prevention of cardiovascular disease in the UK: trends, determinants and lifestyle behaviours
On the genetic and environmental intersection of mental and physical health
Genetic heterogeneity of respiratory disorders
Predictors of successful cognitive ageing and well-being: impact of sleep, physical activity and neuromodulators on age-related changes in frontoparietal connectivity
Comprehensive genome-exposome-phenome association studies for complex diseases
Construction of Multi-dimensional Statistical Shape Model for a heart
Genetics of complex diseases, comorbidities, and other traits in multi-ethnic samples
Risk and protective factors for MRI markers of cerebral small vessel disease
Validation of heritability estimation software and subtyping algorithms in stroke, epilepsy, and Chronic Obstructive Pulmonary Disease (COPD) using UK BioBank electronic health record and genomic data
Efficient Gene-Environment Interaction Tests in Large Samples
Brain anatomy and substance use
Leveraging UK Biobank data to inform on genetics of epilepsy, psychosis and complications in kidney transplant
Genetic determinants of breast cancer prognosis and aggressivity – a phenome-wide association study
Exploring the effects of genome structural variation on human health and disease
Topic Modeling for Phenomewide Studies in Biobanks
Genetic analyses of age-of-onset in cerebral small vessel disease
Examining the causal relationship between health outcomes and socioeconomic status through Mendelian Randomization.
Statistical Method Development for Phenome-Wide Association Studies
Validating risk prediction equations for common cancers as possible tools to direct risk-adapted screening and prevention: a cohort study using the UK Biobank
Validating genomic trait prediction algorithms for commercial use with the UK Biobank resource
Identification of gene-environment interactions and causal pathways for obesogenic cardiometabolic diseases
Estimate the causal effect of asthma on risk of obesity using Mendelian randomization
Understanding the role of diet and lifestyle on obesity, cardiovascular health, cancer, mental health and cognitive function
Activity data as an input to EPSRC funded project ‘The Wearable Clinic: Connecting Health, Self and Care’
Associations between air quality, regional brain volumes, cognitive functioning, and neuropsychiatric outcome in middle-aged and older adults: a cross-sectional study
Tags: 41535, air pollution, bipolar disorder, brain morphology, cognition, depression, featured, neurodegeneration
August 2018
Thyroid Dysfunction and Women’s Cancer Risk
Gene-Environment Interplay in the Generation of Health and Education Inequalities (GEIGHEI)
Association tests for structured and multimodal data
Development and validation of a risk prediction model for oesophageal squamous cell carcinoma using cohort studies
Myeloproliferative neoplasms and clonal haematopoiesis
Developing Statistical Methods for Genetic and Imaging Studies of Substance Use and Dependence
Understanding the dose-response relationships between modifiable lifestyle behaviors & environment with chronic disease risk and mortality: Creating simple tools for improving public health
Refining polygenic score performance in diverse populations
The role of diabetes and glycemic traits in diabetic bone disease, utilizing both traditional and molecular epidemiological methods.
The association of sex steroid hormone levels with cancers of the pancreas, kidney, and brain in the U.K. Biobank
Understanding the biological, lifestyle and environmental risks and outcomes for multimorbidity in psychiatric disorders
Prediction models of health and wellness traits based on genetics, anthropometric, and clinical data
Low LDL cholesterol and mortality
Predictive Modeling of Age-related Macular Degeneration with Multimodal and Interpretable Convolutional Neural Networks
Method development and analysis of biobank imaging, behavioral and genetic data
Interstitial lung disease and Idiopathic pulmonary fibrosis, quality of life and physical activity
Workplace exposure to airborne particles and the association with diabetes and dementia in a large population cohort study
Tags: 42084, air pollution, airborne particles, cognition, Dementia, diabetes, featured, occupational
August 2018
Discovering the biological mechanisms underlying glaucoma and neurodegeneration by analysis of genetic and environmental determinants and associations with other systemic traits in the UK Biobank
Multimorbidity and dementia: an observational cohort study using the UK Biobank
Genetics of Vegetarianism
The genetic study of osteosarcopenic obesity
The role of serum-based small molecule antioxidants in preventing and predicting age-related phenotypes and respiratory cancer
Integrated predictive risk models using multimodal imaging and genetics
Tags: 35667, Computer Vision, deep learning, featured, longitudinal, multi-modality, prediction, whole-genome-sequencing
July 2018
Gene and environment association studies in HUNT and UK Biobank
Risk factors for cardiovascular disease in people with schizophrenia
Mediating mechanisms linking anthropometric, lifestyle and dietary risk factors with cancer risk
Development of a computational method to predict disease risk
Major risk factors for Cardiovascular Disease
Predicting longitudinal outcomes in chronic obstructive pulmonary disease
The role of cardiorespiratory fitness and physical behaviours in protecting against premature mortality
Dr Qing Lu, Developing Statistical Methods for Genetic and Imaging Studies of Substance Use and Dependence
Tags: 40967, Complex Traits, featured, GWAS, Imaging, neural network, substance dependence, substance use
July 2018
