We know of some genes that cause high risk of cancers, such as BRCA1/2. Other genes likely exist that also increase such risk, but we have not found them all. This proposal looks at the baseline risk for those genes in cancer-unaffected individuals and then tests them against specific cancer groups. We have programs that can find the bad variants quickly across all samples. Our research will give an overview of such cancer-causing variant burden and provide a landscape that depicts risks due to specific genes in different cancer types.
