Our research aims to explore the influence of genotype and environmental factors on diabetes and its complications by analyzing the health information and multi-omics data of middle-aged and elderly people in the UK biobank database, so as to better prevent and treat diabetes and its complications. Our research will last for 3 years . Through this study, we will have a more comprehensive understanding of the genetic and environmental factors of diabetes and its complications, which is helpful for subsequent prevention and intervention of them.