Published papers
Featured Publications
Association of Body Mass Index With Cardiometabolic Disease in the UK Biobank
Type: article, Author: Donald M. Lyall and Carlos Celis-Morales and Joey Ward, Date: 2017-07-05
Comorbidities in the diseasome are more apparent than real: What Bayesian filtering reveals about the comorbidities of depression.
Type: article, Author: P Marx and P Antal B Bolgar and G Bagdy and B Deakin and G Juhasz , Date: 2017-06-23
Cardiovascular and type 2 diabetes morbidity and all-cause mortality among diverse chronic inflammatory disorders.
Type: article, Author: A Dregan and P Chowienczyk and M Molokhia, Date: 2017-06-10
Last updated on July 7th, 2016
2017 |
K Wijndaele SJ Sharp, NJ Wareham Brage S Mortality Risk Reductions from Substituting Screen-Time by Discretionary Activities Journal Article In: Medicine and Science in Sports Exercise, 2017. Abstract | Links | BibTeX | Tags: 262, mortality, screen time @article{Wijndaele2017, title = {Mortality Risk Reductions from Substituting Screen-Time by Discretionary Activities}, author = {K Wijndaele, SJ Sharp, NJ Wareham, S Brage }, url = {https://www.ncbi.nlm.nih.gov/pubmed/28106621}, year = {2017}, date = {2017-01-19}, journal = {Medicine and Science in Sports Exercise}, abstract = {PURPOSE: Leisure-screen-time, including TV viewing, is associated with increased mortality risk. We estimated the all-cause mortality risk reductions associated with substituting leisure-screen-time with different discretionary physical activity types, and the change in mortality incidence associated with different substitution scenarios. METHODS: 423,659 UK Biobank participants, without stroke, myocardial infarction or cancer history, were followed for 7.6 (1.4) (median (IQR)) years. They reported leisure-screen-time (TV watching and home computer use) and leisure/home activities, categorised as daily-life activities (walking for pleasure; light DIY; heavy DIY) and structured exercise (strenuous sports; other exercises). Iso-temporal substitution modelling in Cox regression provided hazard ratios (95% confidence intervals) for all-cause mortality when substituting screen-time (30 minutes/day) with different discretionary activity types of the same duration. Potential impact fractions (PIFs) estimated the proportional change in mortality incidence associated with different substitution scenarios. RESULTS: During 3,202,105 person-years of follow-up, 8,928 participants died. Each 30 minute/day difference in screen-time was associated with lower mortality hazard when modelling substitution of screen-time by an equal amount of daily-life activities (0.95 (0.94-0.97)), as well as structured exercise (0.87 (0.84-0.90)). Re-allocations from screen-time into specific activity subtypes suggested different reductions in mortality hazard (walking for pleasure (0.95 (0.92-0.98)), light DIY (0.97 (0.94-1.00)), heavy DIY (0.93 (0.90-0.96)), strenuous sports (0.87 (0.79-0.95)), other exercises (0.88 (0.84-0.91))). The lowest hazard estimates were found when modelling replacement of TV viewing. PIFs ranged from 4.3% (30 minute/day substitution of screen-time into light DIY) to 14.9% (TV viewing into strenuous sports). CONCLUSION: Substantial public health benefits could be gained by replacing small amounts of screen-time with daily-life activities and structured exercise. Daily-life activities may provide feasible screen-time alternatives, if structured exercise is initially too ambitious.}, keywords = {262, mortality, screen time}, pubstate = {published}, tppubtype = {article} } PURPOSE: Leisure-screen-time, including TV viewing, is associated with increased mortality risk. We estimated the all-cause mortality risk reductions associated with substituting leisure-screen-time with different discretionary physical activity types, and the change in mortality incidence associated with different substitution scenarios. METHODS: 423,659 UK Biobank participants, without stroke, myocardial infarction or cancer history, were followed for 7.6 (1.4) (median (IQR)) years. They reported leisure-screen-time (TV watching and home computer use) and leisure/home activities, categorised as daily-life activities (walking for pleasure; light DIY; heavy DIY) and structured exercise (strenuous sports; other exercises). Iso-temporal substitution modelling in Cox regression provided hazard ratios (95% confidence intervals) for all-cause mortality when substituting screen-time (30 minutes/day) with different discretionary activity types of the same duration. Potential impact fractions (PIFs) estimated the proportional change in mortality incidence associated with different substitution scenarios. RESULTS: During 3,202,105 person-years of follow-up, 8,928 participants died. Each 30 minute/day difference in screen-time was associated with lower mortality hazard when modelling substitution of screen-time by an equal amount of daily-life activities (0.95 (0.94-0.97)), as well as structured exercise (0.87 (0.84-0.90)). Re-allocations from screen-time into specific activity subtypes suggested different reductions in mortality hazard (walking for pleasure (0.95 (0.92-0.98)), light DIY (0.97 (0.94-1.00)), heavy DIY (0.93 (0.90-0.96)), strenuous sports (0.87 (0.79-0.95)), other exercises (0.88 (0.84-0.91))). The lowest hazard estimates were found when modelling replacement of TV viewing. PIFs ranged from 4.3% (30 minute/day substitution of screen-time into light DIY) to 14.9% (TV viewing into strenuous sports). CONCLUSION: Substantial public health benefits could be gained by replacing small amounts of screen-time with daily-life activities and structured exercise. Daily-life activities may provide feasible screen-time alternatives, if structured exercise is initially too ambitious. |
2016 |
F Patterson Malone SK, Lozano Grandner MA Hanlon AL A Smoking, Screen-Based Sedentary Behavior, and Diet Associated with Habitual Sleep Duration and Chronotype: Data from the UK Biobank. Journal Article In: Annals of behavioural medicine, 2016. Abstract | Links | BibTeX | Tags: 3474, screen time, sleep, smoking @article{Patterson2016b, title = {Smoking, Screen-Based Sedentary Behavior, and Diet Associated with Habitual Sleep Duration and Chronotype: Data from the UK Biobank.}, author = {F Patterson, Malone SK, Lozano A, Grandner MA, Hanlon AL}, url = {http://www.ncbi.nlm.nih.gov/pubmed/?term=Smoking%2C+Screen-Based+Sedentary+Behavior%2C+and+Diet+Associated+with+Habitual+Sleep+Duration+and+Chronotype%3A+Data+from+the+UK+Biobank}, year = {2016}, date = {2016-07-04}, journal = {Annals of behavioural medicine}, abstract = {BACKGROUND: Sleep duration has been implicated in the etiology of obesity but less is known about the association between sleep and other behavioral risk factors for cardiovascular disease. PURPOSE: The aim of this study was to examine the associations among sleep duration, chronotype, and physical activity, screen-based sedentary behavior, tobacco use, and dietary intake. METHODS: Regression models were used to examine sleep duration and chronotype as the predictors and cardiovascular risk factors as outcomes of interest in a cross-sectional sample of 439,933 adults enrolled in the UK Biobank project. RESULTS: Short sleepers were 45 % more likely to smoke tobacco than adequate sleepers (9.8 vs. 6.9 %, respectively). Late chronotypes were more than twice as likely to smoke tobacco than intermediate types (14.9 vs. 7.4 %, respectively). Long sleepers reported 0.61 more hours of television per day than adequate sleepers. Early chronotypes reported 0.20 fewer daily hours of computer use per day than intermediate chronotypes. Early chronotypes had 0.25 more servings of fruit and 0.13 more servings of vegetables per day than late chronotypes. CONCLUSIONS: Short and long sleep duration and late chronotype are associated with greater likelihood of cardiovascular risk behaviors. Further work is needed to determine whether these findings are maintained in the context of objective sleep and circadian estimates, and in more diverse samples. The extent to which promoting adequate sleep duration and earlier sleep timing improves heart health should also be examined prospectively.}, keywords = {3474, screen time, sleep, smoking}, pubstate = {published}, tppubtype = {article} } BACKGROUND: Sleep duration has been implicated in the etiology of obesity but less is known about the association between sleep and other behavioral risk factors for cardiovascular disease. PURPOSE: The aim of this study was to examine the associations among sleep duration, chronotype, and physical activity, screen-based sedentary behavior, tobacco use, and dietary intake. METHODS: Regression models were used to examine sleep duration and chronotype as the predictors and cardiovascular risk factors as outcomes of interest in a cross-sectional sample of 439,933 adults enrolled in the UK Biobank project. RESULTS: Short sleepers were 45 % more likely to smoke tobacco than adequate sleepers (9.8 vs. 6.9 %, respectively). Late chronotypes were more than twice as likely to smoke tobacco than intermediate types (14.9 vs. 7.4 %, respectively). Long sleepers reported 0.61 more hours of television per day than adequate sleepers. Early chronotypes reported 0.20 fewer daily hours of computer use per day than intermediate chronotypes. Early chronotypes had 0.25 more servings of fruit and 0.13 more servings of vegetables per day than late chronotypes. CONCLUSIONS: Short and long sleep duration and late chronotype are associated with greater likelihood of cardiovascular risk behaviors. Further work is needed to determine whether these findings are maintained in the context of objective sleep and circadian estimates, and in more diverse samples. The extent to which promoting adequate sleep duration and earlier sleep timing improves heart health should also be examined prospectively. |
F Patterson Malone SK, Lozano Grandner MA Hanlon AL A Smoking, Screen-Based Sedentary Behavior, and Diet Associated with Habitual Sleep Duration and Chronotype: Data from the UK Biobank. Journal Article In: Annals of behavioural medicine, 2016. Abstract | Links | BibTeX | Tags: 3474, screen time, sleep, smoking @article{Patterson2016, title = {Smoking, Screen-Based Sedentary Behavior, and Diet Associated with Habitual Sleep Duration and Chronotype: Data from the UK Biobank.}, author = {F Patterson, Malone SK, Lozano A, Grandner MA, Hanlon AL}, url = {http://www.ncbi.nlm.nih.gov/pubmed/?term=Smoking%2C+Screen-Based+Sedentary+Behavior%2C+and+Diet+Associated+with+Habitual+Sleep+Duration+and+Chronotype%3A+Data+from+the+UK+Biobank}, year = {2016}, date = {2016-04-07}, journal = {Annals of behavioural medicine}, abstract = {BACKGROUND: Sleep duration has been implicated in the etiology of obesity but less is known about the association between sleep and other behavioral risk factors for cardiovascular disease. PURPOSE: The aim of this study was to examine the associations among sleep duration, chronotype, and physical activity, screen-based sedentary behavior, tobacco use, and dietary intake. METHODS: Regression models were used to examine sleep duration and chronotype as the predictors and cardiovascular risk factors as outcomes of interest in a cross-sectional sample of 439,933 adults enrolled in the UK Biobank project. RESULTS: Short sleepers were 45 % more likely to smoke tobacco than adequate sleepers (9.8 vs. 6.9 %, respectively). Late chronotypes were more than twice as likely to smoke tobacco than intermediate types (14.9 vs. 7.4 %, respectively). Long sleepers reported 0.61 more hours of television per day than adequate sleepers. Early chronotypes reported 0.20 fewer daily hours of computer use per day than intermediate chronotypes. Early chronotypes had 0.25 more servings of fruit and 0.13 more servings of vegetables per day than late chronotypes. CONCLUSIONS: Short and long sleep duration and late chronotype are associated with greater likelihood of cardiovascular risk behaviors. Further work is needed to determine whether these findings are maintained in the context of objective sleep and circadian estimates, and in more diverse samples. The extent to which promoting adequate sleep duration and earlier sleep timing improves heart health should also be examined prospectively.}, keywords = {3474, screen time, sleep, smoking}, pubstate = {published}, tppubtype = {article} } BACKGROUND: Sleep duration has been implicated in the etiology of obesity but less is known about the association between sleep and other behavioral risk factors for cardiovascular disease. PURPOSE: The aim of this study was to examine the associations among sleep duration, chronotype, and physical activity, screen-based sedentary behavior, tobacco use, and dietary intake. METHODS: Regression models were used to examine sleep duration and chronotype as the predictors and cardiovascular risk factors as outcomes of interest in a cross-sectional sample of 439,933 adults enrolled in the UK Biobank project. RESULTS: Short sleepers were 45 % more likely to smoke tobacco than adequate sleepers (9.8 vs. 6.9 %, respectively). Late chronotypes were more than twice as likely to smoke tobacco than intermediate types (14.9 vs. 7.4 %, respectively). Long sleepers reported 0.61 more hours of television per day than adequate sleepers. Early chronotypes reported 0.20 fewer daily hours of computer use per day than intermediate chronotypes. Early chronotypes had 0.25 more servings of fruit and 0.13 more servings of vegetables per day than late chronotypes. CONCLUSIONS: Short and long sleep duration and late chronotype are associated with greater likelihood of cardiovascular risk behaviors. Further work is needed to determine whether these findings are maintained in the context of objective sleep and circadian estimates, and in more diverse samples. The extent to which promoting adequate sleep duration and earlier sleep timing improves heart health should also be examined prospectively. |
