@article{EppingaRN2016,
title = {Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality},
author = {Eppinga, R. N.
Hagemeijer, Y.
Burgess, S.
Hinds, D. A.
Stefansson, K.
Gudbjartsson, D. F.
van Veldhuisen, D. J.
Munroe, P. B.
Verweij, N.
van der Harst, P.},
url = {https://www.ncbi.nlm.nih.gov/pubmed/27798624},
year = {2016},
date = {2016-12-01},
journal = {Nature Genetics},
abstract = {Resting heart rate is a heritable trait correlated with life span. Little is known about the genetic contribution to resting heart rate and its relationship with mortality. We performed a genome-wide association discovery and replication analysis starting with 19.9 million genetic variants and studying up to 265,046 individuals to identify 64 loci associated with resting heart rate (P < 5 x 10(-8)); 46 of these were novel. We then used the genetic variants identified to study the association between resting heart rate and all-cause mortality. We observed that a genetically predicted resting heart rate increase of 5 beats per minute was associated with a 20% increase in mortality risk (hazard ratio 1.20, 95% confidence interval 1.11-1.28, P = 8.20 x 10(-7)) translating to a reduction in life expectancy of 2.9 years for males and 2.6 years for females. Our findings provide evidence for shared genetic predictors of resting heart rate and all-cause mortality.},
keywords = {genetics, Resting heart rate},
pubstate = {published},
tppubtype = {article}
}