- Once your Registration has been approved, a number of new tabs will become visible on your AMS ‘Home Page’ (example below):
STEP 1: To start a new application, select the ‘Applications’ tab and ‘Start new application’:
- STEP 2: Complete the application form which consists of the following four sections:
- Application details
The purpose of providing an application is for UK Biobank to determine whether the proposed research project is health related, feasible and in the public interest. For this, we require a brief synopsis of the research plan (i.e. a description of the aims, methods and intended outputs) rather than a full scientific view.
A1. Project title – This should be a short description of your proposed project and contain no more than 200 characters.
A2. Research question(s) and aim(s) – Summarise the research questions for your project and what you aim to achieve, containing no more than 200 words.
Do you require biological samples? Yes/No – If you select Yes to this question, you will be required to fill out section C as well as three additional questions in section A3. If you select No to this question, these will not be required as part of your application.
Does your project require UK Biobank to re-contact participants? Yes/No – If you select Yes to this question, you will be required to fill out section D. If you select No to this question, these will not be required as part of your application.
A3. The background and scientific rationale of the proposed research project in general (containing no more than 300 words).
A3.1. The background and scientific rationale for the use of samples, using no more than 300 words. (This question will not be made available to you if you selected No to requiring biological samples).
A3.2. The justification as to why UK Biobank samples in participular are needed for your research (i.e. why can’t appropriate samples be sourced from elsewhere or readily recruited by your research group using no more than 150 words. (This question will not be made available to you if you selected No to requiring biological samples).
A3.3. If you wish to upload further documentation to support your request for requiring samples, please do so here. (This option will not be made available to you if you selected No to requiring biological samples).
A4. A brief description of the method(s) to be used, containing no more than 300 words.
A5. The type and size of dataset required (e.g., case-control subset, men only, Imaging data only, whole cohort, etc), to contain no more than 100 words.
A6. The expected value of the research (taking into account the public interest requirement, containing no more than 100 words.
A7. Up to six keywords which best summarise your proposed research project. Researchers can search for approved projects via a tag cloud based on the keywords entered, eg. Cancer, cognition, diabeties. The entry fields use predictive type-ahead based on commonly used keywords, but please add your own as required.
A8. Please provide a lay summary of your research project in plain english, stating the aims, scientific rationale, project duration and public health impact (up to 400 words). If your research application is approved, the lay summary will be published on the UK Biobank website.
A9. Will the research project result in the generation of any new data-fields derived from existing complex datasets, such as imaging, accelerometry, electrocardiographic, linked healthcare data, etc, which might be of significant utility to other researchers? Yes/No
A10. What is the estimated duration of your project, in months? If you consider (because for example the project is one involving the generation of hypotheses) that it would be difficult to set a fixed end point, we are prepared to consider a rolling 36 month period (during which annual updates are required).
- Selection of data-fields
This part of the application form asks some general questions relating to required data for your research project. In addition, selecting ‘Create application basket’ allows you to create an application basket within our data showcase and add data-fields needed for your research.
B1. Would you like to access an existing copy of the genotyping dataset held at your institute? Yes/No
B2. Would you like to access an existing copy of other bulk data files (e.g., imaging and eye scans, accelerometer data, fitness bike ECG, hospital or primary care data) held at your institute? Yes/No
B3. Would you like to re-use an existing dataset already held at your institute to conduct your research (i.e. that contains all the data you need fo this new project)? Yes/No
- Selection of samples (This section only becomes available if you answer yes to requiring biological samples).
The purpose of this section is to clarify precisely which type of samples are required for your application, as well as your intended use for those samples.
C1. What are the sample type(s), volume(s) and number(s) of samples required? Please refer to the online help for guidance including, for example, information on how DNA was extracted.
- Sample type and collection period can be selected using the dropdowns provided and the remaining criteria can be filled out using free-text.
- You can request multiple sample types within the same application and can do so by selecting ‘Request another sample type’.
C2. If you are intending that an external lab (i.e. not UK Biobank) will conduct the assay, please provide brief details of the proposed lab, the proposed and the related quality control protocol using no more than 150 words.
C3. If you wish to upload documentation to support the proposed aassay(s) and quality control, please do so here:
- Re-contacting participants (This section only becomes available if you answer yes to requiring UK Biobank to re-contact participants).
Although our participants have consented to be re-contacted, they have not consented to be re-contacted on demand. As such, decisions on whether re-contact is justifiable and appropriate will be made by UK Biobank, with advice from the Ethics and Governance Council, and such re-contact requires separate approval from a Research Ethics Committee (and UK Biobank will generally also require independent scientific review to help ensure that re-contact is warranted).
D1. Please consult the guidance on the website relating to re-contact applications and provide the scientific justification for and details of the nature of the re-contact using up to 300 words (in order words why does the conduct of your research project require the re-contact of UK Biobank participants)
D2. If you wish to upload further documentation to support your request for re-contact, please do so here (.pdf format only).
- STEP 3: Once you are happy with your application, you can submit by pressing the appropriate button at either the top or bottom of the screen.
- Alternatively, you can save your application as a draft to return to at a later date by pressing ‘Save and continue later’.
- If you would like to abandon your application, you can do so by pressing ‘Cancel’ and don’t save changes.