Approved Research

Inflammation, Immunosenescence, and Immunometabolism in Aging: A Bio-Psycho-Social Approach from Mechanisms, Presentations to Treatments for Healthy Longevity

Lay summary

The immune system plays a critical role in protecting our bodies against diseases and maintaining overall well-being. As we grow older, changes in our immune system can contribute to age-related disorders. Two specific changes, called immunosenescence and inflammaging, have been identified as key factors that can lead to frailty and impact our health as we age. While previous research has highlighted the significance of these changes in the aging process and their association with frailty, there is still a need for a comprehensive study that considers the biological, psychological, and social aspects to unravel the complex causes of inflammation, immunosenescence, and immunometabolism during aging. To address this gap in knowledge, we will conduct a thorough analysis using data from the UK Biobank. Our investigation will explore physiological functions, cognitive functions, social factors, dietary habits, exercise patterns, and their interaction influence on our immune system. We will also consider other variables that might impact our findings and employ advanced statistical methods to ensure accuracy. The primary goal of this study is to enhance our understanding of how the immune system changes as we age. By uncovering the underlying mechanisms behind these changes, we may be able to develop new treatments that target age-related immune issues, thereby promoting healthier aging. Moreover, this research will provide valuable insights into the intricate relationship between our biology, psychology, and social factors throughout the aging process. Overall, this study has the potential to make a significant impact in the field of geriatrics and gerontology. It may pave the way for the development of innovative therapies that specifically address immune-related problems associated with aging, ultimately leading to an improved quality of life for older adults.