Principal Investigator: Dr Daisy Janssen
Program Development Centre
Chronic obstructive pulmonary disease (COPD) is a progressive disease,
characterized by a gradual decline in lung function. It is a major course
of morbidity and mortality worldwide. Patients with COPD often suffer
from co-morbidities, such as cardiovascular disease, osteoporosis, and
psychological symptoms. Previous studies suggest that cognitive
functioning might be impaired in patients with COPD and may even
predict mortality and disability. However, the exact relationship
between lung function and cognitive functioning remains unknown.
Results of existing studies concerning this relationship are inconsistent.
Several studies suggest that physical activity is associated with the
maintenance and improvement in cognitive function in COPD. Further
studies are needed to explore this relationship. Understanding of the
relationship between lung function, physical activity and cognitive
functioning may help to prevent, to recognize and to develop optimal
care programs for patients with impairment in lung function and
cognitive impairment. Therefore, the aims of this study are:
1) to compare cognitive functioning between patients with and without
2) to analyse the relationship between severity of impairment in lung
function and severity of cognitive impairment;
3) to study the relationship between cognitive functioning and the level
of physical activity in persons with and without COPD.
This project requires the use of data only (relating to medical conditions
at baseline, cognitive function and physical activity) on the full cohort.
This project will help us to understand how cognitive impairment is
related to COPD, which may have important consequences for the
management of the condition.