Principal Investigator: Dr John Gallacher
Department: Primary Care & Public Health
Institution: Cardiff University
Primary Care and Public Health
Cardiff, CF14 4YS
The proposal is to investigate the impact of three classic risk factors
(smoking, alcohol and adiposity, each of which can affect many different
diseases) on a wide range of health outcomes in UK Biobank. Of
particular interest will be vascular outcomes and cancer along with
cognitive performance and mood. This study will contribute to a greater
understanding of how these classic risk factors combine to affect
The initial focus of this work will be to analyse baseline data comparing
risk of major chronic disease according to smoking behaviour, alcohol
consumption and adiposity. When re-measurement data become
available we will use these to improve the precision of our analyses.
When prospective data become available we will extend our analyses to
include incidence and mortality. Outcome data of interest will include
death, cancer registry data and hospital episode data. When bio-marker
data become available we will investigate possible mechanisms
underlying the associations of these three risk factors with prevalent and
incident outcomes. When genetic data become available we will use
these to investigate the interaction between genetic and environmental
factors and to further investigate possible mechanisms.
The value of the proposed analyses lies in the statistical power that is
available from using the entire UK Biobank cohort.
This will enable us to provide the most detailed analyses of these important causes of
morbidity and mortality to date.