Principal Investigator: Mr Yutong Cai
Department: Epidemiology and Biostatistics
Institution: Imperial College London
Imperial College London, Epidemiology and Biostatistics,
Norfolk Place, St Mary Campus, London, W2 1PG
Research has reported harmful effects of ambient air pollution and road traffic
noise on the human cardiorespiratory system. However, there are few studies
to date looking at these two environmental risk factors jointly to investigate
the cardiovascular and respiratory effects. This proposed project aims to
quantify the separate and joint effects of air pollution and noise exposure on
cardiovascular and respiratory outcomes at the individual level, specifically
cardiovascular diseases (ICD-10 codes I00-I99), Asthma (ICD-10 codes J45) and
levels of bio-chemical markers for cardiovascular diseases including blood
lipids, C-reactive protein, blood glucose.
We propose to use the whole cohort of UK Biobank to address our research
questions. Questionnaire data including demographic, socioeconomic, and
lifestyle data will be requested. Health outcome data will be ascertained both
on the basis of self-report and medical records. Inpatient data with regards to
all incident hospital admissions according to primary and underlying admissions causes coded under ICD-10 I00-I99 (cardiovascular diseases) will be
requested. We also request data from death registry linkage-coded according
to underlying (primary) and contributory (secondary) ICD-10 I00-I99. The
asthma outcome will be ascertained by self-reported data at this stage.
These data will be harmonised in line with those from four other cohorts
involved in this BioSHaRE-funded project, namely HUNT(Norway), Lifelines (the
Netherlands), EPIC-Oxford (UK), EPIC-Turin (Italy). Environmental exposure
data (air pollution and noise) at the time of recruitment were created through
linkage of individual address data to geocoded databases at Imperial College,
London. The ultimate objective is to pool harmonised data from these five
Biobanks including UK Biobank for epidemiological analysis.
This project fits well with the UK Biobank’s central aim. It will help to better
understand the environmental determinants of cardio-respiratory disease by
disentangling the health effects of these two exposures and thereby inform
targeted preventive strategies and contribute to scientific knowledge.