Principal Investigator: Dr Soren Brage
Department: Epidemiology Unit
Institution: University of Cambridge
MRC Epidemiology Department, Medical Research Council, Epidemiology Unit,
University of Cambridge, Institute of Metabolic Science, Box 285,
Addenbrooke’s Hospital, Cambridge, Cambridgeshire BC2 0QQ, United
1a: Few large-scale epidemiological studies have included measures of cardiorespiratory
fitness, but those that have indicate that it is strongly related to
metabolic disease, cardiovascular outcomes, some cancers, and all-cause
mortality. Some recent estimates from Health Survey for England (2008)
indicate mean levels of fitness to be around 32 and 36 ml O2/min/kg for adult
women and men, respectively. It is generally agreed, however, that this
represents an overestimate due to stringent exclusion criteria (>40%).
The exercise test used in UK Biobank was designed to be as inclusive as
possible to maximise the potential for linkage with incident disease. More
1b: exercise protocols were individualised to take into account participant
characteristics including risk category. This proposal aims to derive fitness
indicators from information collected during the exercise test, and describe
their variation by appropriate subgroups. Finally, we aim to demonstrate the
etiological utility of derived fitness measures by examining the cross-sectional
association with blood pressure and arterial stiffness.
Approved Project Extension:
We wish to add mortality outcomes to both of these data releases to follow through on the cross-sectional analyses to harder end points. This would allow us to better examine the causal pathway between lifestyle factors (sedentary behaviour and physical activity), fitness measures (muscular and cardiorespiratory fitness), intermediate cardiovascular outcomes (arterial stiffness, blood pressure), and hard endpoints. I did also look at the HES data (data field category 2000), as Reviewers may well ask about incident cardiovascular disease outcomes such as stroke, MI and thrombosis.