Principal Investigator: Associate Professor Pim van der Harst
Department: Cardiology, Genetics
University Medical Center Groningen, Cardiology, Genetics, Hanzeplein 1,
Groningen, 9700RB, Netherlands
1a: Resting heart rate is associated with increased incidence of
cardiovascular disease as well as with other cardiovascular all-cause
mortality. The aim of this study is to explore new insights into the
mechanisms regulating heart rate and identify new therapeutic targets.
1b: The purpose of UK Biobank is to build a major resource that can
support a diverse range of research intended to improve the prevention,
diagnosis and treatment of illness and the promotion of health throughout
society. To gain more insight into the genetic regulation of heart rate, we
are now performing a GWAS meta-analysis with imputation on the 1000G
(March 2012) reference panel. The goal is to get fresh insights into the
mechanisms regulating heart rate, its relevance for clinical outcomes, and
identify new therapeutic targets.
1c: We will perform a genome-wide association study meta-analysis on the
phenotype heart rate. We will combine GWAS data from different cohorts
to find significant single nucleotide polymorphism (SNPS). From the loci
associated with heart rate we will then create a genetic predisposition
score (GPS). Additionally we will test whether the meta-analysis identified
loci show evidence of association with heart conditions registered via
hospital in-patient data (including atrial fibrillation, conduction-related
disorders, myocardial infarction and heart failure) and mortality via deathregister.
We will also test candidate genes in silico and in vitro follow-up.
1d: Major GWAS meta-analysis consortium, aimed at including >200,000
subjects from >100 sites.