Principal Investigator: Dr Marilyn Cornelis
Department: Feinberg School of Medicine
Northwestern University, Feinberg School of Medicine, Preventive Medicine, 680 N Lake Shore Drive, Suite 1400, Chicago IL 60611, United States.Tags: 14791, Coffee, diabetes, Genotype, Hypertension, Mendelian randomization, obesity
Collaborating Institutions and Addresses:
Uppsala University, Department of Medical Sciences, UCR/MTC, Dag Hammarskjolds vag 14B, Uppsala 7523, Sweden.
Summary of research
Coffee,diabetes,hypertension,obesity,genotype, Mendelian Randomization
Application Lay Summary:
1a: Epidemiological studies support inverse associations between coffee intake and cardiometabolic traits, but provide no insight to causality or mechanisms. The latter may be addressed by Mendelian randomization and gene-coffee interaction studies. To investigate the causal and mechanistic role of coffee in cardiometabolic health we aim to
1) Assess observational associations of coffee consumption with T2D, CVD and related-biomarkers
2) Identify genetic variants associated with coffee consumption and to develop robust instrumental variables (IVs) and pathway genetic scores (GSs)
3) Study the causal and mechanistic role of coffee consumption for development of T2D and CVD
1b: Coffee is one of the most widely consumed beverages in the world and thus represents a significant opportunity to positively affect cardiometabolic health globally. In efforts to establish causality and potential mechanisms we are proposing health-related research that is in public interest and thus we believe our study meets the UK Biobank’s purpose.
1c: We will first explore the observational associations of coffee consumption with incident T2D, CHD, ischemic and hemorrhagic stroke, HF and risk factors for T2D and CVD (Aim 1). We will then identify genetic variants associated with coffee consumption and develop robust GS for use in any genetic epidemiological analysis of coffee and health (Aim 2). Finally, we apply these GS in studies of the causal and mechanistic role of coffee consumption for development of T2D and CVD using Mendelian randomization (MR) and gene-coffee interaction frameworks (Aim 3).
1d: Full cohort