Principal Investigator: Dr. Yann Klimentidis
Department: Epidemiology and Biostatistics
University of Arizona, Epidemiology and Biostatistics, 1295 N. Martin,
Tucson AZ 85724, USA
1a: The aim of the proposed research is to identify genetic variants which are
associated with either one circulating biomarker or with several circulating
biomarkers at once, and how these associations differ across racial/ethnic
groups, medication use, lifestyle factors, and prevalent disease status. We are
principally interested in biomarkers and diseases related to obesity, body
composition, and lipid levels.
1b: Since these circulating biomarkers are major clues to health status and
disease risk, the overarching purpose of this research is to better understand the
etiology of major diseases such as type-2 diabetes and heart disease. With this
improved etiological and molecular understanding, it may be possible to develop
or improve therapeutics, and/or otherwise improve prediction and prevention of
1c: We will essentially be looking for links between genetic variants, and
biomarkers, disease, and body composition. We will consider all genetic variants
which are available, and we will also focus on previously established/known
genetic markers. We will look for genetic variants that are associated with
biomarkers, disease status, body composition, lifestyle factors, and
anthropometric traits. We will use standard statistical procedures such as linear
and logistic regression, as well as multivariate regression.
1d: We would like to use the full cohort.