Principal Investigator: Professor Ewan Pearson
Department: Cardiovascular and Diabetes Medicine
Institution: University of DundeeTags: 20405, drug response, progression, Type 2 diabetes
1a: Patients with type 2 diabetes have variable response to treatment, and variable rates of progression of underlying disease. Response and progression are difficult to disentangle as progression encompasses underlying drug response. The research questions are:
What are the clinical, drug drug interaction and genetic predictors of drug response and how do these predictors differ between different diabetes drug treatments.
What is the variability in rate of diabetes progression between individuals, and what are the clinical and genetic predictors of variability in diabetes progression. How do non-diabetes drugs impact on diabetes progression?
1b: This project aims to improve the treatment of type 2 diabetes by gaining insight into the clinical and biological mechanisms that determine response to drugs and underlying diabetes progression. This will enable a stratified approach to therapy and the potential for development of novel therapies in this area.
1c: We will use the clinical data obtained from GP records in UK Biobank to define how individuals with Type 2 diabetes respond to drug treatment, and how their diabetes progresses over time. We have developed statistical and genetic models for these outcomes within the Scottish health record data and will test and extend these in the large UK Biobank dataset.
1d: Full cohort
Project extension approved by UK Biobank on 03/11/2017:
“We want to expand the study, broadly in line with the original approval, by addressing the following research questions: 1) how antidiabetic drugs interact with other environment such as diet and physical activity to influence diabetes progression; 2) how does long term administration of antidiabetic drugs affect health outcome beyond diabetes. For example, the potential anti-aging or anti-cancer impact of first line antidiabetic agent metformin; 3) how do antidiabetic and other drugs interact with each other and how is this influenced by genotype?”