Principal Investigator: Professor Elina Hyppönen
Department: University of South Australia, Centre for Population Health Research, SAHMRI, North Terrace, Adelaide, SA 5000, Australia
1) Professor Joseph Selvanayagam
2) Dr Vimal Karani
Collaborating Institutions and Addresses:
1) Flinders University, School of Medicine, Sturt Road, Bedford Park SA 5042, Australia
2) University of Reading, Hugh Sinclair Nutrition Unit, Whiteknights Campus, Reading, RG6 6AP, United KingdomTags: 20175, diet, featured, Genetic, health, nutrition, obesity, VitaminD
1a: Using approaches from observational and genetic epidemiology, we propose to examine causal effects and gene-environment interactions affecting the way diet, obesity, or other nutritional factors affect health. The project has a specific focus on obesity and vitamin D, but it will also look at coffee, alcohol, and other components affecting nutritional intakes. Diet and nutritional status have a fundamental influence on health, and we will look at influences on aging, endocrinological, cardiovascular, metabolic and musculoskeletal health. This study will establish new disease prevention strategies, and inform on the way we can overcome disease inducing genetic vulnerabilities by lifestyle choices.
1b: This study will aim to establish new disease prevention strategies, and inform on the way we can overcome disease inducing genetic vulnerabilities by lifestyle choices.
1c: This study will use observational and genetic epidemiological approaches using existing information. We will conduct Mendelian randomisation (MR) analyses using genetic proxy markers for variations in nutritional exposures to evaluate the causal effects on the outcome. Analyses will be bi-directional where direction of association is not known, and network MR analyses will be conducted to establish causal pathways. Gene-environment interaction analyses will be conducted to establish effect modification by dietary and nutritional indicators in the way genes affect health.
1d: Full cohort
Our application already covers bi-directional MR analyses, including the exploration of mediating pathways, and we wish to explicitly expand the scope of our application to cover MR and GxE analyses in the context of disease related exposures, and possible drug target related approaches which could be used to mitigate related effects. In addition to nutritional factors, we wish to include broader information on other lifestyle factors such as physical activity. We aim to use clustering approaches to define patterns for individual risk factor profiles, in order to better cover human exposome. We wish to update the methods description to include phenome-wide analyses.