Principal Investigator: Dr Eri Fukaya
Department: Stanford University, Vascular Medicine, 300 Pasteur Drive, Suite H3634 MC5642, Stanford CA 94305. United States
Lead Collaborators: 1) Professor Erik Ingelsson
Collaborating Institutions and Addresses: 1) Uppsala University, Department of Medical Sciences, UCR/MTC, Dag Hammarskjölds väg 14B, Uppsala 75237. Sweden.
Funding body: Stanford University
1a: Peripheral vascular disease is a common condition with a complex and multifactorial development involving interplay between the genetic makeup of the individual and predisposing risk factors including age, female sex, family history. The aims of this project include studies of genetic and environmental determinants of peripheral vascular disease by analyzing genetic predisposition and exposures assessed in the UK Biobank.
1b: We believe that our specific aim of understanding the genetic underpinnings of peripheral vascular disease meets UK Biobank’s stated purpose “aim of improving the prevention, diagnosis and treatment of a wide range of serious and life-threatening illnesses”.
1c: The full UK Biobank cohort is going to be used for this project, Health information including family history will be incorporated in the analysis to improve the ability to obtain accurate predictions of inheritable disease. We hope to uncover genetic variations leading to new knowledge on the development of peripheral vascular disease. This will help to identify opportunities for primary prevention, and to improve the possibilities to target individuals at highest risk for developing disease.
1d: Full cohort