Principal Investigator: Dr John Grogan
Department: University of Bristol, School of Social and Community Medicine, Office OS4, Oakfield House,Oakfield Grove, Bristol, BS8 2BN, United Kingdom
Institution: University of Bristol
1a: We aim to see whether the volumes of different parts of the hippocampus (a brain area involved in memory) are associated with performance on cognitive measures. We predict that people with greater volumes in these areas will have better performance on cognitive measures, such as pairs matching and prospective memory, and that this effect will be greater with age.
1b: It will examine whether sizes of hippocampal subfields affect memory performance (also with age as a covariate). This will show whether healthy age-related decline in memory is due to deterioration of the hippocampus, and which subfields in particular.
1c: We will use automatic algorithms to calculate the sizes of each hippocampal subfield from MRI images, and then use for associations between these and the cognitive measures. We will also look at the effects on the cognitive measures from the follow-up testing.
1d: All participants who completed at least one brain MRI scan (one or more of T1, T2 FLAIR, T2/PD scans).