Principal Investigator: Dr Marilyn Cornelis
Department: Feinberg School of Medicine Preventive Medicine
Northwestern University, Feinberg School of Medicine
Preventive Medicine, 680 N Lake Shore Drive, Suite 1400, Chicago IL 60611Tags: 21394, biomarker, cardiometabolic, Coffee, genetics, omic
1a: Coffee is one of the most widely consumed beverages in the world, and may provide a safe, effective, and readily available preventive/therapeutic agent against multiple diseases and conditions. We are currently studying known and novel metabolite markers of coffee consumption that are amendable to genetic modification. In the current proposal we extend this work by conducting candidate gene-coffee interaction studies on cardiometabolic traits and cognitive function in the UK Biobank cohort.
1b: Coffee is one of the most widely consumed beverages in the world and thus represents a significant opportunity to positively affect
cardiometabolic health globally. In efforts to identify mechanisms by which coffee impacts health we are proposing health-related research that is in public interest and thus we believe our study meets the UK Biobank’s purpose.
1c: We are currently conducting metabolomic and genomic studies of coffee consumption using population-based and clinical based designs. Confirmed metabolite loci will be used to derive genetic scores for coffee exposure and applied in tests of gene -coffee interactions on cardiometabolic traits and cognitive function in the UK Biobank cohort (N~500,000).
1d: Full cohort for data analysis
Previous studies suggest caffeine might be especially beneficial for cognitive function in the elderly. At the same time, age-related cognitive decline is a well-known phenomenon after age 65 but little is known about earlier changes and prior studies are based on relatively small samples. Thus, we will additionally investigate the impact of age on cognitive decline in this large population sample.
Project extension – December 2019
Another primary source of caffeine, particularly in the UK, is tea. We therefore wish to extend the scope of this project to include analysis of tea but also other sources of caffeine including fizzy drinks.
Last updated Dec 17, 2019