Principal Investigator: Professor Dominic Furniss
Institution: University of OxfordTags: 11571, epidemiology, Fibrosis, genetics
Lead Collaborators: 1) Professor Andrew Morris
Collaborating Institutions and Addresses: 1) University of Liverpool,
Department of Biostatistics
Liverpool L69 3GA
1a: Fibrosis is a pathological response of the body to a wide variety of insults. It is characterised by scarring in the wrong place. This is a common end point for many diseases, including conditions such as heart disease, dementia and liver cirrhosis. Taken as a whole, it is estimated that fibrosis contributes to up to 45% of deaths worldwide.
We wish to study the genetic and non-genetic factors that predispose to fibrosis. In particular, we are interested in any factors that predispose to multiple different types of fibrosis, to identify underlying mechanisms that might lead to new treatments.
1b: This research is wholly focussed on improving the health of the nation, and is clearly in the public interest.
1c: We will analyse genetic and non-genetic data from participants who suffer from a variety of conditions that are characterised by fibrosis, including Dupuytren’s Disease, Endometriosis, Uterine Fibroids, Frozen Shoulder, Pulmonary and Hepatic Fibrosis, and Systemic Sclerosis / Scleroderma. By analysing the data both separately and together, we hope to discover common factors that predispose to fibrosis in general that are not detectable by analysing the groups individually.
1d: We intend to analyse the full cohort.
“We have found in a large dataset from General Practice, that Dupuytren’s Disease is associated with increased risk of death from cardiovascular disease (IHD and stroke), lung disease (COPD), and cancer (including various subtypes). We are interested in whether we can see this in the secondary care data that is available in UKB, as well as whether other fibrotic diseases are also associated with increased risk of death from these causes. We then want to look for any shared genetic predisposition to cancer and fibrosis (and the other causes of death and fibrosis). To do this, we need the most accurate codes for case ascertainment, hence requesting the cancer codes.”