Principal Investigator: Professor Richard Houlston
Department: Molecular and Population Genetics
Institution: Institute of Cancer ResearchTags: 8508, biomarkers, bowel, cancer, featured, genetics, risk factors
Lead collaborators: 1) Professor Ian Tomlinson
Collaborating Institution address: 1) University of Oxford, Wellcome Trust Centre for Human Genetics, Nuffield Dept. of Clinical Medicine, Roosevelt Drive, Oxford OX3 7BN United Kingdom
Funding body: grant awarded by Cancer Research UK
1a: Knowledge of colorectal cancer (CRC) risk factors can be translated into improvements in prevention and early detection of CRC through risk stratification of the population and tailoring interventions according to risk. Paramount to this is the development of risk stratification models from prospective cohort studies, and the discovery of novel biomarkers of CRC risk.
- a) To develop a risk prediction model for CRC that incorporates genetic, lifestyle and biomarker information
- b) To discover CRC risk alleles and new biomarkers predictive of CRC risk
- c) To evaluate the performance of new risk prediction models under development including environmental, biomarker and genetic information.
1b: The proposed research will result in development of a model for prediction of CRC that can be implemented in risk-stratified strategies for the prevention and early detection of CRC.
1c: We would like to request an extract of raw data on CRC risk factors and outcomes (colorectal polyps or cancer, other major diseases, survival) for participants in the UK Biobank. These data will be processed to derive variables for our analyses.
1d: Members of any age participating in the full UK Biobank cohort, but subset acceptable where data are not available on all participants.