Principal Investigator: Dr. Christopher Kabrhel
Massachusetts General Hospital, Emergency Medicine, Zero Emerson Place, Suite 3B, Boston MA 02114, United StatesTags: 25298, environment, featured, gene, pulmonary embolism, Venous thromboembolism
Lead Collaborators: 1) Professor Peter Kraft
Collaborating Institutions and Addresses: 1) Harvard School of Public Health, Department of Epidemiology, 655 Huntington Avenue, Boston MA 02115, United States
Lead Collaborators: 2) Dr Sara Lindstroem
Collaborating Institutions and Addresses: 2) University of Washington, Department of Epidemiology, 1959 NE Pacific Street, Health Sciences Building, F-247B, Seattle WA 98195, United States
1a: The proposed research aims to identify novel genetic risk factors for venous thromboembolism (VTE), a common and potentially fatal disease of blood clotting, and to study the interaction between genetic factors and several established environmental risk factors for VTE.
1b: As many as one million individuals are affected by VTE each year in the US and Europe and annual VTE-related deaths are estimated at 370,000 (Europe). Given the high prevalence and disease severity, more research on the causes, prevention, and treatment of VTE is urgently needed. The proposed research will “improve the prevention, diagnosis and treatment of illness and the promotion of health throughout society“ by providing insight into the basic pathophysiology of VTE, improve our ability to assess the risk of developing venous blood clots and help us design strategies to prevent VTE in the general population.
1c: This research aims to identify inherited genetic differences that alter the risk of developing a condition called venous thromboembolism (VTE). With VTE, a blood clot develops in a large vein (usually in the leg) and can travel to the lung causing difficulty breathing and stress on the heart. We will compare the genomes of individuals with VTE to individuals without VTE. We will also study non-genetic risk factors for VTE such as smoking and obesity to learn how genetics and the environment interact to affect VTE risk.
1d: We request data from all individuals in the cohort in order to identify matched controls to the VTE cases in the UK Biobank. For each case (N~4,000), we will identify four controls matched on sex, age at DNA collection and previous cancer (yes/no).
Our expanded project will build on our previous genetic discoveries by creating a risk prediction model for VTE. To facilitate this, we are now planning to assess the association between blood cell traits, selected biomarkers and incident VTE. Our risk prediction model will therefore include genetic, environmental/lifestyle, and biomarker data. We will derive our risk prediction model using UK Biobank data, and will validate our model in an independent longitudinal cohort of women and men from the United States.
Last updated Oct 14, 2019