Until now, UK Biobank, a health data resource aiming to help scientists discover why some people develop particular diseases and others do not, had limited mental health data to work with. Following 157,366 responses to an online mental health questionnaire (MHQ) developed by researchers from King’s College London, alongside collaborators from across the UK, it now has unparalleled potential for further biomedical research in mental health, dramatically expanding potential research into mental disorders.
Professor Matthew Hotopf, Director of the NIHR Maudsley Biomedical Centre, who chaired the expert working group said, ‘Our study suggests that UK Biobank could be a powerful tool for mental health research, and since it is open to all health researchers for work in the public good, we hope to inspire both existing and new users of UK Biobank.
Our mental health questionnaire demonstrates the substantial burden of mental disorders. Given the known impact of mental health on physical health, mental health data should interest researchers from every biomedical specialty looking at associations with health and disease.’
Access to this data will give researchers the opportunity to look at whether, for example, depression is one illness or lots of different related illnesses.
An expert working group designed the questionnaire to capture enough data to characterise participants as having a lifetime history of depression and other phenotypes.
The researchers worked with a service user advisory group at the NIHR Biomedical Research Centre at the South London and Maudsley NHS Foundation Trust in designing the questionnaire and invitation to participants.
The questionnaire also underwent larger-scale piloting in 13,000 volunteers aged 50 years or older who had signed up to the PROTECT study on cognitive ageing. The implementation of this questionnaire demonstrates that a web-based questionnaire is an acceptable means of collecting mental health information at low cost and large scale.
The findings have been published today in BJPsych Open:
This paper represents independent research funded by the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London. The MHQ was developed and administered with UK Biobank funding.
Read more about the UK Biobank Thoughts and Feelings questionnaire and how to take part if you are a participant here: https://www.ukbiobank.ac.uk/thoughts-and-feelings/