Principal Investigator: Dr Ben Brumpton
Norwegian University of Science and Technology, Trondheim, NorwayTags: 40135, epidemiology, Meta-analysis, PheWAS, Replication
We aim to use UK Biobank to support current research projects in the HUNT by replicating GWAS, MR and observational study findings. The HUNT dataset included comprehensive questionnaires, clinical examinations and interviews. More than 14,000 unique questions or measurements. We therefore request a range of data matching or complementing our existing data.
Within Norway there are a limited number of population based studies that can be used for replication. Studies with genotyped data are especially sparse. Using the UK Biobank will provide an opportunity to replicate health related research findings in a more than suitably large population with similar population characteristics. Comparing across populations is especially important for causal inference. Biased estimates due to selection bias, population stratification, the underlying confounding structures in the population and other systematic biases can undermine study findings. Replicating results in a second cohort such as UK Biobank will help to reduce the reporting of erroneous results and strengthen study findings.
We expect that the project will run for a minimum of five years and be updated as required.
The utilization of both cohorts (HUNT and UK biobank) will improve public health research by increasing the power to detect associations, the precision of estimates and the robustness of findings, and therefore improve public health.
Project extension – May 2020
In addition, we would like to use UK Biobank to create prediction models which we will evaluate/validate in HUNT and vice versa. The UK Biobank data will be used to support prediction studies of disease and health related traits in HUNT. Many research projects on prediction have been established on topics including but not limited to mental health and sepsis.
Last updated May 18, 2020