Principal Investigator: Dr Mizanur Khondoker
University of East Anglia, Norwich, UKTags: 34684, Dementia, Mediators, moderators, multimorbidity, Risk
Background/scientific rationale: People with dementia, on average, have an additional 4.6 chronic conditions, many of which may start before the onset of dementia. The co-occurrence of multiple chronic diseases/conditions in one person is termed “multimorbidity”. Emerging evidence suggests that multimorbidity is associated with poorer cognitive health in older age, but whether multimorbidity increases the risk of developing dementia is yet to be established. Currently there is a lack of large scale, population based, rigorous longitudinal studies investigating the impact of multimorbidity on the risk of developing dementia.
Aims: We aim to investigate if co-occurrence of multiple chronic diseases/conditions in older age increases the risk of developing dementia. We also want to understand which combinations of chronic conditions is more or less harmful in terms of developing dementia. Furthermore, we will explore if/how other factors, including socio-economic, lifestyle, environmental and genetic factors, influence the link between multimorbidity and dementia. For example, whether the effect of multimorbidity on dementia risk is higher (or lower) in people living in the most deprived areas compared with the most affluent.