Principal Investigator: Professor Mathias Fasshauer
Justus Liebig University of Giessen, GermanyTags: 47144, cardiovascular disease, featured, gluten intake, metabolic-syndrome, mortality
Although study results are contradictory, gluten intake has been linked to increasing health risks. Therefore, gluten-limited and gluten-free diets gained popularity also among healthy people without coeliac disease. The main reason for buying gluten-free products is that they are considered to be healthier than their conventional counterparts. However, a gluten-free diet may result in limited food choice and an unbalanced diet which is low in iron, zinc, folate, niacin, and fibre. Furthermore, to the best of our knowledge dietary gluten intake of UK Biobank participants has not been assessed so far.
This research aims to assess:
– The average dietary gluten intake of UK Biobank participants (aim 1)
– Whether gluten intake is associated with facets of the metabolic syndrome and vascular disease (cross-sectional study; aim 2)
– Whether gluten intake predicts all-cause and cardiovascular mortality (prospective study; aim 3)
In summary, the study will provide further evidence whether or not a gluten-limited or gluten-free diet is part of a healthy lifestyle. The research project is in line with the aims of UK biobank, i.e. to improve the prevention of serious public health risks like metabolic syndrome and cardiovascular disease.
We expect a project duration of 12 months.
Project extension – February 2020:
The average gluten intake for UK Biobank participants is estimated from the web-based 24-h dietary assessment data (aim 1).
Average gluten intake data are then used to address the following three research questions: Is gluten intake associated with
- Facets of the metabolic syndrome and vascular disease, i.e. markers of visceral obesity, arterial hypertension, dyslipidaemia, insulin resistance/ impaired glucose tolerance, subclinical inflammation, coronary artery disease, and stroke (cross-sectional study; aim 2)?
- All-cause and cardiovascular mortality, i.e. hazard ratios using Cox proportional hazards models (prospective study; aim 3)?
3. Incidence of specific health-related outcomes including metabolic disease and cancer subtypes, i.e. hazard ratios using Cox proportional hazards models (prospective study; aim 4)?
Last updated Feb 24, 2020