Principal Investigator: Professor Asa Johansson
Uppsala University (Sweden)Tags: 41143, Breastfeeding, contraceptive pills, featured, oily fish, omega-3
In this project, we will evaluate the health-related effects of three common exposures on population health. The aims are to:
1) to determine the optimal level of oily fish consumption in order to maximize the bifacial effects, to investigate if omega-3 supplement can replace oily fish intake, and to compare to the effects seen in individuals carrying genetic variants that allow for faster biosynthesis of the fatty acids that are present in oily fish.
2) investigate the relative risk of disease in women taking contraceptive pills compared to women not taking contraceptive pills and how this risk differs in women carrying a genetic variant associated with increased risk for venous thrombosis
3) investigate the relative risk of disease in persons that have been breastfeed in compared to persons that not have been breastfeed.
Oily fish intake and omega-3 supplements as well as use of contraceptive pills and weather a person has been breastfeed or not, are common factors that have been associated with many health effects. We will therefore investigate a wide spectrum of diseases and disease-traits as health outcomes including: cardiovascular diseases (acute myocardial infarction, cerebral infarction, intra cerebral haemorrhage, hypertension, atherosclerosis, deep vein thrombosis, pulmonary embolism), some of the most common cancers (breast, cervical, ovarian, colorectal, endometrial, kidney), benign breast disease, inflammatory diseases (rheumatoid arthritis, osteoarthritis, irritable bowel syndrome, inflammatory bowel disease), atopic diseases (asthma, allergy, allergic rhinitis, eczema), mental health issues (depression, anxiety, panic attacks), diabetes (type I and II), osteoporosis, fluid intelligence and educational attainment.
Many common exposures have been associated with variable risk for disease risk. However, we also know that exposures have variable effects in different groups of individuals depending on for example sex, age, socioeconomic status or on genetic factors. Using data from UK biobank, will allow for more precise results which can lead to a better understanding of the causal effect of different exposures on disease risk. The main rationale for this project is that the society needs clear recommendations for diet, lifestyle and use of different pharmaceuticals which will help the individuals as well as the healthcare system to make more qualified choices/recommendations which will result in better population health.
The data analyses will take place during 2018 and writing of manuscripts and presentation results during 2019. We expect the results from the project to be published in late 2019.
Project extension – December 2019
To investigate the relative risk of disease in women and men exposed to high levels of endogenous hormones (biomarkers: oestradiol, testosterone and SHBG), and women that have given birth to many children or that are exposed to endogenous exogenous hormones (oral contraceptive pills or hormone replacement therapy). We aim to perform observational studies as well as studying effects of genetic variants in relevant genes and perform Mendelian randomization analyses.
Last updated Dec 13, 2019