Principal Investigator: Dr Kaixiong Ye
University of Georgia (USA)Tags: 48818, biomarkers, Causal Effects, Clinical Outcomes, Dietary Supplements, genetics, Mendelian randomization
Taking dietary supplements could be an effective means of managing health and
preventing diseases. The specific health benefits of a dietary supplement have to
be evaluated by a clinical trial, which is usually resource-intensive and
complicated. An innovative statistical method, called Mendelian randomization,
provides a cost-effective alternative to evaluate the causal effect of a specific
environmental exposure on a clinical outcome. Our research will develop
computational tools implementing this kind of methods and apply them to
available data in the UK Biobank. We will un-biasedly evaluate the relationship
between all diet-modifiable biomarkers and clinical outcomes. We expect the
proposed project will take three years in implementation and then another year
in the publication of findings and software. Our research will demonstrate the
presence or absence of causal benefits of a biomarker on a clinical condition.
These discoveries will guide our future practice of dietary recommendation.