Principal Investigator: Professor John Gallacher
Institution: University of Oxford
Professor Simon Moore – Cardiff University, Cardiff, UK
Dr Chinmoy Sarkar – University of Hong Kong, Hong Kong
Dr Giovanni Piumatti – University of Geneva, Geneva, Switzerland
To determine the life-course effects of alcohol misuse and hazardous use on health and well-being – including injury, mental health, emotional and cognitive development and decline, and on educational attainment and health service utilisation. This will be done by cross-cohort analyses including UK Biobank, ALSPAC, The Health and Social Needs study and The Caerphilly Study.
The current proposal is not linked to the DPUK project.
We wish to include alcohol price data in models considering the environment and alcohol use. Specifically, ONS price quotes are available publicly by UK region. We would link assessment centre to ONS region to include price data alongside the Biobank cohort. The reason for this is that while environment and alcohol has been studied, as has price and consumption, no study has yet considered how price and environment interact.
We wish to extend the health harms associated with alcohol use and analyse diet more generally. Specifically, to consider the eating habits of drinkers cross-sectionally. Due to the voluminous nature of the dietary information contained within Biobank we aim to leverage machine learning algorithms in this endeavour. The issue being that if dietary choice varies by consumption then it is feasible those identified as misusing alcohol should receive more general dietary advice in addition.
We wish to extend our understanding of the relationship between alcohol use and depressive symptoms by comparing their longitudinal interactions with contextual factors. The dominant model of the relationship cannot account for those who drink to deal with depressive symptoms. We would construct a graph of putative causal factors and evaluate their effects across time using machine learning. We aim to understand the contexts in which alcohol use drives depression vs contexts in which depression drives alcohol use. This has direct implications for individuals at risk as it will provide insights into which issue should receive focus.