Principal Investigator: Professor Sabine Rohrmann
Department: University of ZurichTags: 55149, in-situ-breast-cancer, lifestyle, pre-diagnostic, prevention, recommendations, score
Few studies have investigated potential risk factors for in situ breast cancer . Although the association between in situ breast cancer risk and few individual risk factors has been investigated, analyses on diet and lifestyle in relation to in situ breast cancer from large studies are missing.
The World Cancer Research Fund/American Institute for Cancer Research has recently published nine cancer prevention recommendations. Adherence to these recommendations has been associated with reduced cancer incidence and mortality, including reduced invasive breast cancer risk. However, to our knowledge, no study has investigated the association between adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention recommendations and in situ breast cancer risk.
In the analysis anticipated, each of the potentially modifiable World Cancer Research Fund/American Institute for Cancer Research cancer prevention recommendation will be scored, as in previous publications. The sum of the single recommendations will then constitute the score used to assess the risk of in situ breast cancer development. Since in situ breast cancer is mainly detected through mammographic screening, we will utilize the mammographic information in the UK Biobank (mammographic screening attendance, time since last mammogram) as covariates and stratifying variables in our analyses.
We aim to investigate whether adherence to the potentially modifiable World Cancer Research Fund/American Institute for Cancer Research cancer prevention recommendations is associated with in situ breast cancer development overall and by socioeconomic characteristics in the UK.