Principal Investigator: Dr Ningjian Wang
Department: Shanghai Ninth People's Hospital
Collaborating institutes –
Professor Christian Benedict – Uppsala University, Sweden
Dr Jihui Zhang – Chinese University of Hong Kong, ChinaTags: 57733, birth-weight, cardiometabolic, cardiovascular disease, Mendelian randomisation
The rising prevalence of cardiometabolic diseases has been recognized as a public health problem globally. Observational studies have suggested that low birth weight may increases the risk for CVD and metabolic disease in adulthood. However, we do not have enough evidence to verify whether there have causal associations between low and high birth weight and multiple cardiovascular conditions in large-scale cohorts. Therefore, we intend to study causal effects of low and high birth weight on multiple cardiovascular conditions and metabolic diseases. This project will last for 36 months. Findings from this research may establish causal effect of low and high birth weight on cardiovascular conditions and metabolic diseases. These findings will pave a way for future preventive strategies for cardiovascular conditions and metabolic diseases by modifying factors closely associated with birth weight, such as prenatal nutrition status.
Project extension – July 2020
New scope: The causal role of high and low birth weight for multiple human common diseases, especially chronic diseases needs to be further comfirmed. This project aims to apply the Mendelian randomization design to investigate the associations of birth weight with cardiovascular conditions, metabolic diseases, cancer, chronic pulmonary diseases, chronic kidney diseases and some form of endocrine disorders (thyroid, osteoporosis, etc.).
Last updated Jul 2, 2020