Cognitive aging and obesity are major health concerns of the 21st century and have recently been the focus of extensive biomedical research. However, the relationship between body weight and brain/cognitive health across the adult lifespan remain largely unexplored. An emerging line of evidence suggests a complex interaction between aging and body mass index (BMI) such that high BMI is disruptive in young/middle aged adults but neuroprotective in older adults. We propose to investigate imaging, physiological, cognitive, and lifestyle characteristics to determine the interaction between body weight and aging on brain health. UK Biobank data resource provides a unique opportunity to identify individually predictive patterns of brain structure and function associated with aging and obesity. The expected results will clarify the intriguing relationship between body weight and brain health in adult development, an important step towards understanding successful cognitive aging. The proposed research therefore is in accordance with UK Biobank’s stated purpose to support research projects intended to improve the prevention and diagnosis of illness and the promotion of health throughout society. We will analyse neuroimaging data together with the physiological and behavioural markers using deep neural networks to identify complex neuromarkers of brain health that are influenced by body weight and aging. To estimate the efficacy of the proposed deep learning algorithms the obtained results will be compared to those gained from traditional factor analysis and machine learning algorithms. The proposed data-driven approach involving deep neural networks to identify complex neuromarkers of brain health that are influenced by body weight and aging require data sets as large as possible. Therefore, we intend to analyse the full cohort for which brain imaging data is available to maximize the predictive power of our analysis.
