Both insomnia and substance use disorder cause significant public health and socioeconomic burden. People with substance use disorder are likely to comorbid with insomnia, and individuals who have sleeping problems may abuse alcohol or illicit drugs or prescription medications. The mechanisms underlying altered sleep performance following the substance use disorder process are unknown. The neural basis of the increased functional connectivity for the substance use disorder with insomnia is unknown neither. We could identify neural and genetic mechanisms that mediate the association of insomnia and substance use disorder. The whole program will last about 3 years. It will help us to develop new strategies of treatment for insomnia symptoms in patients with substance use disorder.
