Aims: We aim to investigate the morphology and genetic link between brain function and two major categories of bone disease, namely degenerative and rheumatic bone disease.
Scientific rationale: Certain nerve dysfunctions may affect bone homeostasis via a central-to-peripheral circuit. In humans, central nervous-acting medications have a very profound effect on bone homeostasis characterized by altered nerve tension. Moreover, diseases like Alzheimer’s disease and traumatic brain injury have a complex role in bone mass. Animal studies have shown that manipulating certain brain function and region have a potential protective role on bone disease. However, it remains unclear how these orthopedic disorders affect brain function in humans. If
Projection duration: This project will last for approximately 36 months for data analysis, interpretation of results, and drawing the final conclusion.
Public health impact: New techniques can be applied to manipulate the function of these brain regions and may have a potential influence on bone health. These non-invasive or mini-invasive methods targeting the central nervous system may be a new avenue to prevent or treat orthopedic diseases. If an effective method has been developed to prevent the exacerbation of orthopaedic disease, fewer surgeries or medications are needed to treat these diseases annually. Targeting the brain can effectively alleviate pain caused by bone disease and therefore reduce the usage of painkillers and other medications. The project may contribute to the health of the general public and the effective usage of medical expenses from different aspects.
