The lone atrial fibrillation (AF) refers to AF arsies without any relevant risk factors , which is thought to be a multifactorial, inheritable disease. PRS composed of >100 common genetic variants was demonstrated to have significant association of liketime risk of AF in large cohort, but the role of common genetic variations in lone AF has not been demonstrated. We sought to analyze the impact of common genetic variation in the susceptability of lone AF. Using the UK biobank data, GWAS study will be performed with patients diagnosed with lone AF, defined as AF without relevant risk factors, and controls without AF diagnosis. The study will yield heritability and the proportion of genetic explanation for lone AF, in comparison with those in other studies for all AF patients. Among already known genetic loci associated with AF susceptibility, this study may show more specific genetic variations that are closely related to hereditary AF. The information regarding the role common genetic variant in lone AF would help devlopment of individual diagnostic, therapeutic plan in clinical practices.
