Despite significant progress in treating cardiovascular disease caused by atherosclerosis, it remains the top cause of death worldwide. Even with effective management of common risk factors, there’s still a considerable risk of cardiovascular events. Research has shown that high levels of certain proteins in the blood and markers of inflammation are major factors contributing to this risk.
This study aims to understand the genetic and molecular characteristics associated with inflammation and cardiovascular disease in participants from the UK Biobank. Specifically, we will investigate different types of inflammatory responses in the UK Biobank participants and how they’re influenced by genetics and various substances in the blood. Additionally, we will explore various aspects of heart and metabolic health in the UK Biobank participants, such as cholesterol levels and insulin resistance, and how these factors relate to genetics and blood substances. This study will provide insight into how the immune system and lipoproteins together lead to the genesis of heart disease, findings which will impact our understanding of the pathogenesis of heart disease and allow for more precise management of patients with and at risk of heart disease.