Cardiovascular diseases, which are one of the major health problems around the world along with cancer, were previously thought to be more influenced by acquired environmental factors than abnormalities at the genetic level. Thus, there has been limited progress in introducing precision medicine. However, in recent years, with the development of large-scale biobank data and statistical analysis methods for large-scale data, including genomic data, comprehensive analysis of genetic factors has become possible. Many genetic factors associated with the onset of the disease have been identified. In cardiovascular diseases, it has become clear that although the influence of each genetic factor is small, overlapping genetic factors can have a corresponding influence on the individual, and this is proposed by the concept of polygenic risk score (PRS). Although the several relationships between cardiovascular diseases and genetic factors have been reported, there are many aspects that are still unclear. Thus, further deep consideration would be needed in terms of not only genetic point of view but also clinical point of view.
In this project (over 3 years), we will use the database in UK biobank and analyze the association between specific cardiovascular diseases and genetic factors. In addition, we analyze the association between specific cardiovascular diseases and baseline characteristics including lifestyle, behavior, laboratory data, imaging examinations…etc. while taking genetic factors into consideration. Furthermore, we will try to collaborate other research groups and database, and develop clinically useful tools, such as disease prediction scores, outcomes prediction scores including genetic factors. Thel purpose of the current project is to develop clinically useful tools for doctors at bedside. Thus, the expected value of the research would be great for public health.
