Obesity is a global epidemic, with its prevalence increasing rapidly, especially in regions like Indonesia. While factors like diet and exercise play a role, recent research suggests genetics also influence obesity risk. However, most genetic studies on obesity have focused on European populations, raising questions about their relevance to diverse groups, including Asians. Our project aims to bridge this gap by studying the genetics of obesity across different racial and ethnic groups, particularly in Southeast Asia.
We aim to uncover the genetic factors contributing to obesity susceptibility across diverse populations, including Indonesians. By leveraging data from the UK Biobank, which includes diverse populations, and combining it with our in-house genetic data from Indonesians, we aim to identify genetic markers specific to Asian populations, shedding light on why certain groups may be more susceptible to obesity than others. By doing so, we hope to identify genetic factors specific to Asian populations, shedding light on why certain groups may be more susceptible to obesity than others. This information could lead to tailored interventions and healthcare strategies, particularly beneficial for countries like Indonesia where obesity rates are rising.
Our study will involve advanced genetic analyses to uncover key genetic markers associated with obesity risk. We’ll also explore how these genetic factors interact with lifestyle and environmental factors, providing a comprehensive understanding of obesity’s genetic underpinnings. Importantly, we’ll ensure our research is ethical and inclusive, considering the needs of all populations, including minority groups often underrepresented in genetic studies.
The study duration is expected to be 36 months. Furthermore, our study aims to have a lasting impact that extends beyond the immediate project duration. Our study’s outcomes will inform Indonesian governmental policies aimed at preventing obesity from an early age, particularly if we find higher obesity risks within the Indonesian population. These policies might include additional mandatory teaching materials in schools, raising awareness about behaviors that can trigger obesity. Additionally, by pioneering comprehensive genetic research in Indonesia, our work can catalyze further interest and investment in genomic studies, particularly those utilizing Genome-Wide Association Studies (GWAS). Establishing research sustainability in genomics within Indonesia is crucial, not only for addressing obesity but also for advancing healthcare strategies tailored to the unique genetic makeup of Indonesian populations. This, in turn, could lead to more effective interventions and policies aimed at curbing the obesity epidemic and improving public health outcomes in Indonesia and beyond.