Based on the genotype and phenotype data of complex brain disorders in the UK Biobank, we aim to explore the etiological mechanisms involving genetic-environmental interactions, and identify potential therapeutic targets for complex brain disorders.
Utilizing causal inference methods, we can delve into associations between complex brain disorders or associations between diseases and non-disease phenotypes, aiming to unravel the mechanisms behind the occurrence of complex diseases/traits. We will integrate multi-level and multimodal genetic data, including WGS, WES, imaging data, and metabolomic data, to explore the proportional impact of genetic and environmental factors on the onset of complex diseases/traits. Data obtained from the UK Biobank would be combined with data from other cohorts or data of clinical samples attained from third-generation sequencing / single-cell sequencing / spatial omics sequencing / etc., which can contribute to more reliable research conclusions.
The estimated duration of this project is 36 months.
This project is anticipated to provide more targeted strategies for future treatments and interventions, as well as new biomarkers for early intervention and precise treatment, for complex brain disorders.
