Scientific rationale: Over the past few decades, the burden of morbidity and mortality from cardiovascular disease (CVD) and prostate cancer has been steadily increasing. Given the clinical co-occurrence of CVD and prostate cancer in observational studies, it is reasonable to believe that a recursive relationship may exist between these two diseases.
Major Objective: We aimed to evaluate bidirectional associations between CVD and prostate cancer. Moreover, we assessed whether this bidirectional association differs across genetic risk levels. In addition, we applied MR analysis to evaluate the potential causal relations of two conditions.
Project duration: 3 years
Public health implications: Investigating the recursive relationship between CVD and prostate cancer is important to facilitate the personalized prevention of both diseases. Further insights into cardiac oncology may lead to targeted intervention and treatment for individuals with cancer.