Aims
This research project aims to advance our understanding of cardiovascular-kidney-metabolic (CKM) health. We will investigate how cardiovascular health, psychological well-being, and high adherence to an environmentally friendly diet contribute to cardiovascular and kidney diseases. Additionally, we will evaluate a new cardiovascular risk prediction model inclusive of kidney function indicators and compare it with conventional cardiovascular risk prediction models.
Scientific Rationale
CKM health is a holistic concept recognizing the interconnectedness of cardiovascular, kidney, and metabolic functions. Chronic kidney disease (CKD) and cardiovascular disease (CVD) often coexist, which complicates the prevention and treatment of these conditions. Recent research suggests that maintaining good cardiovascular health, adhering to a balanced healthy diet, and ensuring psychological well-being can lower the risk of CVD while research on their effects on kidney health remains understudied. Our study seeks to leverage the extensive data from the UK Biobank, which includes health information from over 500,000 participants, to provide more insights on CKM health to bridge the research gaps.
Project Duration
The project is expected to last three years, covering data analysis, interpretation, and dissemination of findings.
Public Health Impact
The results of this research could have significant implications for public health. By advancing our understanding of CKM health, we can develop more effective strategies for preventing and managing chronic diseases, leading to better health outcomes and quality of life. Research findings on the effects of maintaining optimal cardiovascular health on adverse kidney outcomes can help inform holistic prevention and treatment strategies to improve prognosis and quality of life among patients with impaired kidney function. Moreover, this research will provide evidence of the benefits of the EAT-Lancet planetary health diet, which promotes human health and supports environmental sustainability. These findings could inform dietary guidelines while adding knowledge of its benefits of enhancing CKM health. By evaluating and comparing various cardiovascular risk scores, including the newly developed PREVENT equation, the study aims to enhance risk prediction for CVD in different populations. This can help healthcare providers identify high-risk individuals and tailor their treatment plans more effectively. Last, the study will explore the impact of mental health on CKM health, highlighting the importance of psychological well-being in managing chronic diseases and this could lead to integrated care approaches that address both physical and mental health needs.
Overall, our findings will contribute to public health strategies aimed at improving CKM health, ultimately enhancing patient outcomes and promoting a healthier population.