Inflammatory bowel disease (IBD), which includes ulcerative colitis (UC) and Crohn’s disease (CD), is a chronic inflammatory disease of the gastrointestinal tract whose causative factors and mechanisms are unclear. Since inflammatory bowel disease is prone to recurring episodes, this leads to serious challenges to both the physical and mental health of the patient. Previous studies have shown that IBD patients are at increased risk of cardiovascular disease and mental disorder problems. In addition, it is generally accepted that IBD has no impact on life expectancy after treatment. However, the exact effects of IBD on cardiac size and function, cognitive performance, accelerated biological aging, and mortality are currently unclear. Our study aims to shed more light on these associations and to better understand the mechanisms between IBD and bowel cancer from micro perspectives.
Our study aims are listed as follows:
1. To analyze the associations between inflammatory bowel disease (IBD) and cardiac magnetic resonance, mental health, accelerated biological aging, pan-cancer and all-cause mortality.
2. To study the interaction effect of Lifestyle and Polygenic Risk Scores on IBD.
3. To study the mechanisms between IBD and bowel cancer by multi-omics data.
